XIAP and Ki-67: A Correlation Between Antiapoptotic and Proliferative Marker Expression in Benign and Malignant Tumours of Salivary Gland: An Immunohistochemical Study
Background: Impaired balance between cell proliferation and apoptosis is crucial to the development of malignant neoplasm. The purpose of this study was to evaluate and compare the expression of X-Linked inhibitor of apoptotic protein (XIAP) (antiapoptotic marker) and Ki-67 (proliferative marker...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2015-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5604/11690_CE(RA1)_F(T)_PF1(NJAK)-1_PFA(AK)_PF2(PAG)_u.pdf |
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| author | Bhupesh Bhayyaji Bagulkar Madhuri Gawande Minal Chaudhary Amol Ramchandra Gadbail Swati Patil Smita Bagulkar |
| author_facet | Bhupesh Bhayyaji Bagulkar Madhuri Gawande Minal Chaudhary Amol Ramchandra Gadbail Swati Patil Smita Bagulkar |
| author_sort | Bhupesh Bhayyaji Bagulkar |
| collection | DOAJ |
| description | Background: Impaired balance between cell proliferation and
apoptosis is crucial to the development of malignant neoplasm.
The purpose of this study was to evaluate and compare the
expression of X-Linked inhibitor of apoptotic protein (XIAP)
(antiapoptotic marker) and Ki-67 (proliferative marker) expression
in benign and malignant salivary gland (SG) tumours.
Materials and Methods: The study consisted of 40 cases of
benign SG tumours and 50 cases of malignant SG tumours. The
immunohistochemistry was carried out by using Ki-67 antibody
(clone MIB-1) and XIAP antibody in all the groups.
Results: XIAP expression was significantly higher in malignant
SG tumours than benign SG tumours (p = 0.016). Ki-67 LI was
significantly higher in malignant SG tumours than benign SG
tumours (p = 0.0002). Statistically significant positive correlation
between Ki-67 count and XIAP expression was noted in benign
and malignant SG tumours (p = 0.000).
Conclusion: As the expression of an antiapoptotic marker (XIAP)
increases, the expression of a proliferative marker (Ki-67) also
increases from benign to malignant SG tumours. Thus, targeted
therapy of XIAP may play a future role in the management of SG
malignancy. |
| first_indexed | 2024-12-11T07:19:44Z |
| format | Article |
| id | doaj.art-39ba3586d0164bf4be5165572b0e3aca |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T07:19:44Z |
| publishDate | 2015-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-39ba3586d0164bf4be5165572b0e3aca2022-12-22T01:16:07ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-02-0192EC01EC0410.7860/JCDR/2015/11690.5604XIAP and Ki-67: A Correlation Between Antiapoptotic and Proliferative Marker Expression in Benign and Malignant Tumours of Salivary Gland: An Immunohistochemical StudyBhupesh Bhayyaji Bagulkar0Madhuri Gawande1Minal Chaudhary2Amol Ramchandra Gadbail3Swati Patil4Smita Bagulkar5Assistant Professor, Department of Oral and Maxillofacial Pathology and Microbiology, Sri Aurobindo College of Dentistry, Indore, Madhya Pradesh, India.Professor, Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India.Professor and Head, Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India.Associate Professor, Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India.Professor, Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India.Lecturer, Department of Oral and Maxillofacial Surgery, Sri Aurobindo College of Dentistry, Indore, Madhya Pradesh, India.Background: Impaired balance between cell proliferation and apoptosis is crucial to the development of malignant neoplasm. The purpose of this study was to evaluate and compare the expression of X-Linked inhibitor of apoptotic protein (XIAP) (antiapoptotic marker) and Ki-67 (proliferative marker) expression in benign and malignant salivary gland (SG) tumours. Materials and Methods: The study consisted of 40 cases of benign SG tumours and 50 cases of malignant SG tumours. The immunohistochemistry was carried out by using Ki-67 antibody (clone MIB-1) and XIAP antibody in all the groups. Results: XIAP expression was significantly higher in malignant SG tumours than benign SG tumours (p = 0.016). Ki-67 LI was significantly higher in malignant SG tumours than benign SG tumours (p = 0.0002). Statistically significant positive correlation between Ki-67 count and XIAP expression was noted in benign and malignant SG tumours (p = 0.000). Conclusion: As the expression of an antiapoptotic marker (XIAP) increases, the expression of a proliferative marker (Ki-67) also increases from benign to malignant SG tumours. Thus, targeted therapy of XIAP may play a future role in the management of SG malignancy.https://jcdr.net/articles/PDF/5604/11690_CE(RA1)_F(T)_PF1(NJAK)-1_PFA(AK)_PF2(PAG)_u.pdfapoptosisbenign and malignant salivary gland tumoursinhibitor of apoptotic protein (iap)ki-67x-linked inhibitor of apoptotic protein (xiap) |
| spellingShingle | Bhupesh Bhayyaji Bagulkar Madhuri Gawande Minal Chaudhary Amol Ramchandra Gadbail Swati Patil Smita Bagulkar XIAP and Ki-67: A Correlation Between Antiapoptotic and Proliferative Marker Expression in Benign and Malignant Tumours of Salivary Gland: An Immunohistochemical Study Journal of Clinical and Diagnostic Research apoptosis benign and malignant salivary gland tumours inhibitor of apoptotic protein (iap) ki-67 x-linked inhibitor of apoptotic protein (xiap) |
| title | XIAP and Ki-67: A Correlation Between Antiapoptotic and Proliferative Marker Expression in Benign and Malignant Tumours of Salivary Gland: An Immunohistochemical Study |
| title_full | XIAP and Ki-67: A Correlation Between Antiapoptotic and Proliferative Marker Expression in Benign and Malignant Tumours of Salivary Gland: An Immunohistochemical Study |
| title_fullStr | XIAP and Ki-67: A Correlation Between Antiapoptotic and Proliferative Marker Expression in Benign and Malignant Tumours of Salivary Gland: An Immunohistochemical Study |
| title_full_unstemmed | XIAP and Ki-67: A Correlation Between Antiapoptotic and Proliferative Marker Expression in Benign and Malignant Tumours of Salivary Gland: An Immunohistochemical Study |
| title_short | XIAP and Ki-67: A Correlation Between Antiapoptotic and Proliferative Marker Expression in Benign and Malignant Tumours of Salivary Gland: An Immunohistochemical Study |
| title_sort | xiap and ki 67 a correlation between antiapoptotic and proliferative marker expression in benign and malignant tumours of salivary gland an immunohistochemical study |
| topic | apoptosis benign and malignant salivary gland tumours inhibitor of apoptotic protein (iap) ki-67 x-linked inhibitor of apoptotic protein (xiap) |
| url | https://jcdr.net/articles/PDF/5604/11690_CE(RA1)_F(T)_PF1(NJAK)-1_PFA(AK)_PF2(PAG)_u.pdf |
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