Fabrication of hydroxyapatite-baghdadite nanocomposite scaffolds coated by PCL/Bioglass with polyurethane polymeric sponge technique
Objecttive (s): Silicate bioceramics like Baghdadite with chemical formula Ca3ZrSi2O9, has attracted the attention of researchers in biomedical field due to its remarkable in-vitro and in-vivo bioactivity and mechanical properties.Materials and Methods: Therefore, in the current study the baghdadite...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2017-07-01
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| Series: | Nanomedicine Journal |
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| Online Access: | http://nmj.mums.ac.ir/article_8959_6e74748fd9f7ad1dd7b20db746f49618.pdf |
| _version_ | 1818055633925046272 |
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| author | Ebrahim Karamian Akram Nasehi Saeed Saber-Samandari Amirsalar Khandan |
| author_facet | Ebrahim Karamian Akram Nasehi Saeed Saber-Samandari Amirsalar Khandan |
| author_sort | Ebrahim Karamian |
| collection | DOAJ |
| description | Objecttive (s): Silicate bioceramics like Baghdadite with chemical formula Ca3ZrSi2O9, has attracted the attention of researchers in biomedical field due to its remarkable in-vitro and in-vivo bioactivity and mechanical properties.Materials and Methods: Therefore, in the current study the baghdadite powder with Sol-Gel method was synthesized. Then, hydroxyapatite/Baghdadite (HA/Bagh) scaffolds were prepared by the replacing the polyurethane polymeric sponge technique. Afterwhile, the ceramic scaffolds were sintered at 1150ºC for 3 h. The prepared scaffold was then coated by polycaprolactone/bioglass (PCL/BG) polymer nanocomposite. Results: Bioactivity and biomineralization in the simulated body fluid (SBF) revealed that the nanocomposite scaffolds coate with PCL/BG had significant bioactivity properties. The morophology and microstructure investigation of soaked samples in SBF indicate that bone-like apatite formed on the surfaces. Also, ion release in SBF containing the scaffolds was measured by inductively coupled plasma (ICP) analysis. The nucleation positions of apatite crystals were areas with high silicon containing, Si+4 ion positions.Conclusion: The study indicates that scaffold containing 30 wt. % baghdadite had proper bioactivity behaviordue to its ability to form bone-like apatite on the surface of specimens. |
| first_indexed | 2024-12-10T12:16:03Z |
| format | Article |
| id | doaj.art-39badc2ad9b84a71a8268232c47514e0 |
| institution | Directory Open Access Journal |
| issn | 2322-3049 2322-5904 |
| language | English |
| last_indexed | 2024-12-10T12:16:03Z |
| publishDate | 2017-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj.art-39badc2ad9b84a71a8268232c47514e02022-12-22T01:49:13ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042017-07-014317718310.22038/nmj.2017.89598959Fabrication of hydroxyapatite-baghdadite nanocomposite scaffolds coated by PCL/Bioglass with polyurethane polymeric sponge techniqueEbrahim Karamian0Akram Nasehi1Saeed Saber-Samandari2Amirsalar Khandan3Advanced Materials Research Center, Faculty of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, IranAdvanced Materials Research Center, Faculty of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, IranNew Technologies Research Center, Amirkabir University of Technology, Tehran, IranYoung Researchers and Elite Club, Khomeinishahr Branch, Islamic Azad University, Isfahan, IranObjecttive (s): Silicate bioceramics like Baghdadite with chemical formula Ca3ZrSi2O9, has attracted the attention of researchers in biomedical field due to its remarkable in-vitro and in-vivo bioactivity and mechanical properties.Materials and Methods: Therefore, in the current study the baghdadite powder with Sol-Gel method was synthesized. Then, hydroxyapatite/Baghdadite (HA/Bagh) scaffolds were prepared by the replacing the polyurethane polymeric sponge technique. Afterwhile, the ceramic scaffolds were sintered at 1150ºC for 3 h. The prepared scaffold was then coated by polycaprolactone/bioglass (PCL/BG) polymer nanocomposite. Results: Bioactivity and biomineralization in the simulated body fluid (SBF) revealed that the nanocomposite scaffolds coate with PCL/BG had significant bioactivity properties. The morophology and microstructure investigation of soaked samples in SBF indicate that bone-like apatite formed on the surfaces. Also, ion release in SBF containing the scaffolds was measured by inductively coupled plasma (ICP) analysis. The nucleation positions of apatite crystals were areas with high silicon containing, Si+4 ion positions.Conclusion: The study indicates that scaffold containing 30 wt. % baghdadite had proper bioactivity behaviordue to its ability to form bone-like apatite on the surface of specimens.http://nmj.mums.ac.ir/article_8959_6e74748fd9f7ad1dd7b20db746f49618.pdfCoatingNanocompositePolymerPolyurethane polymeric sponge techniqueScaffolds |
| spellingShingle | Ebrahim Karamian Akram Nasehi Saeed Saber-Samandari Amirsalar Khandan Fabrication of hydroxyapatite-baghdadite nanocomposite scaffolds coated by PCL/Bioglass with polyurethane polymeric sponge technique Nanomedicine Journal Coating Nanocomposite Polymer Polyurethane polymeric sponge technique Scaffolds |
| title | Fabrication of hydroxyapatite-baghdadite nanocomposite scaffolds coated by PCL/Bioglass with polyurethane polymeric sponge technique |
| title_full | Fabrication of hydroxyapatite-baghdadite nanocomposite scaffolds coated by PCL/Bioglass with polyurethane polymeric sponge technique |
| title_fullStr | Fabrication of hydroxyapatite-baghdadite nanocomposite scaffolds coated by PCL/Bioglass with polyurethane polymeric sponge technique |
| title_full_unstemmed | Fabrication of hydroxyapatite-baghdadite nanocomposite scaffolds coated by PCL/Bioglass with polyurethane polymeric sponge technique |
| title_short | Fabrication of hydroxyapatite-baghdadite nanocomposite scaffolds coated by PCL/Bioglass with polyurethane polymeric sponge technique |
| title_sort | fabrication of hydroxyapatite baghdadite nanocomposite scaffolds coated by pcl bioglass with polyurethane polymeric sponge technique |
| topic | Coating Nanocomposite Polymer Polyurethane polymeric sponge technique Scaffolds |
| url | http://nmj.mums.ac.ir/article_8959_6e74748fd9f7ad1dd7b20db746f49618.pdf |
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