Dynamic Regulation of GH–IGF1 Signaling in Injury and Recovery in Hyperoxia-Induced Neonatal Lung Injury

Dynamic Regulation of GH–IGF1 Signaling in Injury and Recovery in Hyperoxia-Induced Neonatal Lung Injury

Prematurely born infants often require supplemental oxygen that impairs lung growth and results in arrest of alveolarization and bronchopulmonary dysplasia (BPD). The growth hormone (GH)- and insulin-like growth factor (IGF)1 systems regulate cell homeostasis and organ development. Since IGF1 is dec...

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Bibliographic Details
Main Authors: Christina Vohlen, Jasmine Mohr, Alexey Fomenko, Celien Kuiper-Makris, Tiffany Grzembke, Rabia Aydogmus, Rebecca Wilke, Dharmesh Hirani, Jörg Dötsch, Miguel A. Alejandre Alcazar
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
neonatal hyperoxia and bronchopulmonary dysplasia
growth hormone and IGF1
lung injury and regeneration
alveolar epithelial type II cell
neonatal lung fibroblast
Online Access:https://www.mdpi.com/2073-4409/10/11/2947

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