SUN PROTECTOR FACTOR (SPF) IN VITRO AND THE PHYSICAL STABILITY OF O/W CREAM OPTIMAL FORMULA FROM THE PARTITION PRODUCT OF MAHKOTA DEWA LEAVES [Phaleria macrocarpa (Scheff) Boerl]
The leaves Mahkota dewa (Phaleria macrocarpa (Scheff) Boerl) contains a benzophenoic glycoside (Phalerin) which is active for sun screen. Some formula and designed on the Simplex Lattice Design (SLD) method then its physical characteristics were investigated. The physical characteristics will be use...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2015-12-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/855 |
| _version_ | 1818317420890161152 |
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| author | Abdul Karim Zulkarnain Marchaban Marchaban Subagus Wahyuono, Ratna Asmah Susidarti |
| author_facet | Abdul Karim Zulkarnain Marchaban Marchaban Subagus Wahyuono, Ratna Asmah Susidarti |
| author_sort | Abdul Karim Zulkarnain |
| collection | DOAJ |
| description | The leaves Mahkota dewa (Phaleria macrocarpa (Scheff) Boerl) contains a benzophenoic glycoside (Phalerin) which is active for sun screen. Some formula and designed on the Simplex Lattice Design (SLD) method then its physical characteristics were investigated. The physical characteristics will be used to determine the optimum formula. In present study, the optimum formulation was evaluated to determine chemical stability and the in vitro SPF. The doses of partition product of P. macrocarpa was used 6%. The optimal formulation cream was determined by SLD version 9.0.1 with variety of Cetyl alcohol, mineral oil, and Tween 80. The difference of physical characteristics between experimental and software was analyzed using T-test, P= 95 %. The physical stability and in vitro SPF of the optimum formula was observed. he study exhibits that the combination of cetyl alchodol 9,71%, mineral oil 29%, and tween 80 3,29% was the optimum formula of o/w cream with the desirability test 0,924. The T-test result test shows that there is no significant difference (p>0.05) on physical characteristics between experimental and software prediction. During the storage, the viscosity, spread ability, adhesive ability, separation volume ratio of cream was relatively stable however the stability started to decline on the week IV in the extreme temperature. The SPF of the cream of the CFR, CPHR and CBZP partition were 21,32; 33,12 and 42,49, respectively. |
| first_indexed | 2024-12-13T09:37:03Z |
| format | Article |
| id | doaj.art-39bca69e60994a76af3000c4a6d77786 |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-13T09:37:03Z |
| publishDate | 2015-12-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-39bca69e60994a76af3000c4a6d777862022-12-21T23:52:18ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862015-12-0126421021810.14499/indonesianjpharm26iss4pp210SUN PROTECTOR FACTOR (SPF) IN VITRO AND THE PHYSICAL STABILITY OF O/W CREAM OPTIMAL FORMULA FROM THE PARTITION PRODUCT OF MAHKOTA DEWA LEAVES [Phaleria macrocarpa (Scheff) Boerl]Abdul Karim Zulkarnain0Marchaban Marchaban1Subagus Wahyuono,2Ratna Asmah Susidarti3Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta. Skip Utara 55291, YogyakartaFaculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta. Skip Utara 55291, YogyakartaFaculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta. Skip Utara 55291, YogyakartaFaculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta. Skip Utara 55291, YogyakartaThe leaves Mahkota dewa (Phaleria macrocarpa (Scheff) Boerl) contains a benzophenoic glycoside (Phalerin) which is active for sun screen. Some formula and designed on the Simplex Lattice Design (SLD) method then its physical characteristics were investigated. The physical characteristics will be used to determine the optimum formula. In present study, the optimum formulation was evaluated to determine chemical stability and the in vitro SPF. The doses of partition product of P. macrocarpa was used 6%. The optimal formulation cream was determined by SLD version 9.0.1 with variety of Cetyl alcohol, mineral oil, and Tween 80. The difference of physical characteristics between experimental and software was analyzed using T-test, P= 95 %. The physical stability and in vitro SPF of the optimum formula was observed. he study exhibits that the combination of cetyl alchodol 9,71%, mineral oil 29%, and tween 80 3,29% was the optimum formula of o/w cream with the desirability test 0,924. The T-test result test shows that there is no significant difference (p>0.05) on physical characteristics between experimental and software prediction. During the storage, the viscosity, spread ability, adhesive ability, separation volume ratio of cream was relatively stable however the stability started to decline on the week IV in the extreme temperature. The SPF of the cream of the CFR, CPHR and CBZP partition were 21,32; 33,12 and 42,49, respectively.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/855Mahkota dewacreamoptimumSPF |
| spellingShingle | Abdul Karim Zulkarnain Marchaban Marchaban Subagus Wahyuono, Ratna Asmah Susidarti SUN PROTECTOR FACTOR (SPF) IN VITRO AND THE PHYSICAL STABILITY OF O/W CREAM OPTIMAL FORMULA FROM THE PARTITION PRODUCT OF MAHKOTA DEWA LEAVES [Phaleria macrocarpa (Scheff) Boerl] Indonesian Journal of Pharmacy Mahkota dewa cream optimum SPF |
| title | SUN PROTECTOR FACTOR (SPF) IN VITRO AND THE PHYSICAL STABILITY OF O/W CREAM OPTIMAL FORMULA FROM THE PARTITION PRODUCT OF MAHKOTA DEWA LEAVES [Phaleria macrocarpa (Scheff) Boerl] |
| title_full | SUN PROTECTOR FACTOR (SPF) IN VITRO AND THE PHYSICAL STABILITY OF O/W CREAM OPTIMAL FORMULA FROM THE PARTITION PRODUCT OF MAHKOTA DEWA LEAVES [Phaleria macrocarpa (Scheff) Boerl] |
| title_fullStr | SUN PROTECTOR FACTOR (SPF) IN VITRO AND THE PHYSICAL STABILITY OF O/W CREAM OPTIMAL FORMULA FROM THE PARTITION PRODUCT OF MAHKOTA DEWA LEAVES [Phaleria macrocarpa (Scheff) Boerl] |
| title_full_unstemmed | SUN PROTECTOR FACTOR (SPF) IN VITRO AND THE PHYSICAL STABILITY OF O/W CREAM OPTIMAL FORMULA FROM THE PARTITION PRODUCT OF MAHKOTA DEWA LEAVES [Phaleria macrocarpa (Scheff) Boerl] |
| title_short | SUN PROTECTOR FACTOR (SPF) IN VITRO AND THE PHYSICAL STABILITY OF O/W CREAM OPTIMAL FORMULA FROM THE PARTITION PRODUCT OF MAHKOTA DEWA LEAVES [Phaleria macrocarpa (Scheff) Boerl] |
| title_sort | sun protector factor spf in vitro and the physical stability of o w cream optimal formula from the partition product of mahkota dewa leaves phaleria macrocarpa scheff boerl |
| topic | Mahkota dewa cream optimum SPF |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/855 |
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