4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer
The ability of tumor cells to evade the immune system is one of the main challenges we confront in the fight against cancer. Multiple strategies have been developed to counteract this situation, including the use of immunostimulant molecules that play a key role in the anti-tumor immune response. Su...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6210 |
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| author | Alejandra G. Martinez-Perez Jose J. Perez-Trujillo Rodolfo Garza-Morales Maria J. Loera-Arias Odila Saucedo-Cardenas Aracely Garcia-Garcia Humberto Rodriguez-Rocha Roberto Montes-de-Oca-Luna |
| author_facet | Alejandra G. Martinez-Perez Jose J. Perez-Trujillo Rodolfo Garza-Morales Maria J. Loera-Arias Odila Saucedo-Cardenas Aracely Garcia-Garcia Humberto Rodriguez-Rocha Roberto Montes-de-Oca-Luna |
| author_sort | Alejandra G. Martinez-Perez |
| collection | DOAJ |
| description | The ability of tumor cells to evade the immune system is one of the main challenges we confront in the fight against cancer. Multiple strategies have been developed to counteract this situation, including the use of immunostimulant molecules that play a key role in the anti-tumor immune response. Such a response needs to be tumor-specific to cause as little damage as possible to healthy cells and also to track and eliminate disseminated tumor cells. Therefore, the combination of immunostimulant molecules and tumor-associated antigens has been implemented as an anti-tumor therapy strategy to eliminate the main obstacles confronted in conventional therapies. The immunostimulant 4-1BBL belongs to the tumor necrosis factor (TNF) family and it has been widely reported as the most effective member for activating lymphocytes. Hence, we will review the molecular, pre-clinical, and clinical applications in conjunction with tumor-associated antigens in antitumor immunotherapy, as well as the main molecular pathways involved in this association. |
| first_indexed | 2024-03-10T10:35:00Z |
| format | Article |
| id | doaj.art-39bd0b4523b243f2b46b91bfc3e611e1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:35:00Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-39bd0b4523b243f2b46b91bfc3e611e12023-11-21T23:20:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212621010.3390/ijms221262104-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against CancerAlejandra G. Martinez-Perez0Jose J. Perez-Trujillo1Rodolfo Garza-Morales2Maria J. Loera-Arias3Odila Saucedo-Cardenas4Aracely Garcia-Garcia5Humberto Rodriguez-Rocha6Roberto Montes-de-Oca-Luna7Department of Histology, School of Medicine, Autonomous University of Nuevo Leon, Monterrey 64460, MexicoDepartment of Histology, School of Medicine, Autonomous University of Nuevo Leon, Monterrey 64460, MexicoInternal Medicine Residency Program, University of Texas Rio Grande Valley, Edinburg, TX 78539, USADepartment of Histology, School of Medicine, Autonomous University of Nuevo Leon, Monterrey 64460, MexicoDepartment of Histology, School of Medicine, Autonomous University of Nuevo Leon, Monterrey 64460, MexicoDepartment of Histology, School of Medicine, Autonomous University of Nuevo Leon, Monterrey 64460, MexicoDepartment of Histology, School of Medicine, Autonomous University of Nuevo Leon, Monterrey 64460, MexicoDepartment of Histology, School of Medicine, Autonomous University of Nuevo Leon, Monterrey 64460, MexicoThe ability of tumor cells to evade the immune system is one of the main challenges we confront in the fight against cancer. Multiple strategies have been developed to counteract this situation, including the use of immunostimulant molecules that play a key role in the anti-tumor immune response. Such a response needs to be tumor-specific to cause as little damage as possible to healthy cells and also to track and eliminate disseminated tumor cells. Therefore, the combination of immunostimulant molecules and tumor-associated antigens has been implemented as an anti-tumor therapy strategy to eliminate the main obstacles confronted in conventional therapies. The immunostimulant 4-1BBL belongs to the tumor necrosis factor (TNF) family and it has been widely reported as the most effective member for activating lymphocytes. Hence, we will review the molecular, pre-clinical, and clinical applications in conjunction with tumor-associated antigens in antitumor immunotherapy, as well as the main molecular pathways involved in this association.https://www.mdpi.com/1422-0067/22/12/62104-1BBLcancer immunologyimmunotherapycancer therapycancer vaccination |
| spellingShingle | Alejandra G. Martinez-Perez Jose J. Perez-Trujillo Rodolfo Garza-Morales Maria J. Loera-Arias Odila Saucedo-Cardenas Aracely Garcia-Garcia Humberto Rodriguez-Rocha Roberto Montes-de-Oca-Luna 4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer International Journal of Molecular Sciences 4-1BBL cancer immunology immunotherapy cancer therapy cancer vaccination |
| title | 4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer |
| title_full | 4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer |
| title_fullStr | 4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer |
| title_full_unstemmed | 4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer |
| title_short | 4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer |
| title_sort | 4 1bbl as a mediator of cross talk between innate adaptive and regulatory immunity against cancer |
| topic | 4-1BBL cancer immunology immunotherapy cancer therapy cancer vaccination |
| url | https://www.mdpi.com/1422-0067/22/12/6210 |
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