A New Variant among Newcastle Disease Viruses Isolated in the Democratic Republic of the Congo in 2018 and 2019
Newcastle disease (ND) is a highly transmissible and devastating disease that affects poultry and wild birds worldwide. Comprehensive knowledge regarding the characteristics and epidemiological factors of the ND virus (NDV) is critical for the control and prevention of ND. Effective vaccinations can...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/2/151 |
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| author | Augustin T. Twabela Lam Thanh Nguyen Justin Masumu Patrick Mpoyo Serge Mpiana Julienne Sumbu Masatoshi Okamatsu Keita Matsuno Norikazu Isoda Bianca Zecchin Isabella Monne Yoshihiro Sakoda |
| author_facet | Augustin T. Twabela Lam Thanh Nguyen Justin Masumu Patrick Mpoyo Serge Mpiana Julienne Sumbu Masatoshi Okamatsu Keita Matsuno Norikazu Isoda Bianca Zecchin Isabella Monne Yoshihiro Sakoda |
| author_sort | Augustin T. Twabela |
| collection | DOAJ |
| description | Newcastle disease (ND) is a highly transmissible and devastating disease that affects poultry and wild birds worldwide. Comprehensive knowledge regarding the characteristics and epidemiological factors of the ND virus (NDV) is critical for the control and prevention of ND. Effective vaccinations can prevent and control the spread of the NDV in poultry populations. For decades, the Democratic Republic of the Congo (DRC) has reported the impacts of ND on commercial and traditional poultry farming systems. The reports were preliminary clinical observations, and few cases were confirmed in the laboratory. However, data on the phylogenetic, genetic, and virological characteristics of NDVs circulating in the DRC are not available. In this study, the whole-genome sequences of three NDV isolates obtained using the next-generation sequencing method revealed two isolates that were a new variant of NDV, and one isolate that was clustered in the subgenotype VII.2. All DRC isolates were velogenic and were antigenically closely related to the vaccine strains. Our findings reveal that despite the circulation of the new variant, ND can be controlled in the DRC using the current vaccine. However, epidemiological studies should be conducted to elucidate the endemicity of the disease so that better control strategies can be implemented. |
| first_indexed | 2024-03-09T04:08:31Z |
| format | Article |
| id | doaj.art-39bd89ba6d9147b3b839994bcf4ba67a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T04:08:31Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-39bd89ba6d9147b3b839994bcf4ba67a2023-12-03T14:02:51ZengMDPI AGViruses1999-49152021-01-0113215110.3390/v13020151A New Variant among Newcastle Disease Viruses Isolated in the Democratic Republic of the Congo in 2018 and 2019Augustin T. Twabela0Lam Thanh Nguyen1Justin Masumu2Patrick Mpoyo3Serge Mpiana4Julienne Sumbu5Masatoshi Okamatsu6Keita Matsuno7Norikazu Isoda8Bianca Zecchin9Isabella Monne10Yoshihiro Sakoda11Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, JapanLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, JapanCentral Veterinary Laboratory of Kinshasa, Kinshasa I/Gombe 012, Democratic Republic of the CongoCentral Veterinary Laboratory of Kinshasa, Kinshasa I/Gombe 012, Democratic Republic of the CongoCentral Veterinary Laboratory of Kinshasa, Kinshasa I/Gombe 012, Democratic Republic of the CongoCentral Veterinary Laboratory of Kinshasa, Kinshasa I/Gombe 012, Democratic Republic of the CongoLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, JapanLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, JapanLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, JapanIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro (Padova), ItalyIstituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro (Padova), ItalyLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, JapanNewcastle disease (ND) is a highly transmissible and devastating disease that affects poultry and wild birds worldwide. Comprehensive knowledge regarding the characteristics and epidemiological factors of the ND virus (NDV) is critical for the control and prevention of ND. Effective vaccinations can prevent and control the spread of the NDV in poultry populations. For decades, the Democratic Republic of the Congo (DRC) has reported the impacts of ND on commercial and traditional poultry farming systems. The reports were preliminary clinical observations, and few cases were confirmed in the laboratory. However, data on the phylogenetic, genetic, and virological characteristics of NDVs circulating in the DRC are not available. In this study, the whole-genome sequences of three NDV isolates obtained using the next-generation sequencing method revealed two isolates that were a new variant of NDV, and one isolate that was clustered in the subgenotype VII.2. All DRC isolates were velogenic and were antigenically closely related to the vaccine strains. Our findings reveal that despite the circulation of the new variant, ND can be controlled in the DRC using the current vaccine. However, epidemiological studies should be conducted to elucidate the endemicity of the disease so that better control strategies can be implemented.https://www.mdpi.com/1999-4915/13/2/151new variantNewcastle disease viruschicken outbreakDemocratic Republic of the Congo |
| spellingShingle | Augustin T. Twabela Lam Thanh Nguyen Justin Masumu Patrick Mpoyo Serge Mpiana Julienne Sumbu Masatoshi Okamatsu Keita Matsuno Norikazu Isoda Bianca Zecchin Isabella Monne Yoshihiro Sakoda A New Variant among Newcastle Disease Viruses Isolated in the Democratic Republic of the Congo in 2018 and 2019 Viruses new variant Newcastle disease virus chicken outbreak Democratic Republic of the Congo |
| title | A New Variant among Newcastle Disease Viruses Isolated in the Democratic Republic of the Congo in 2018 and 2019 |
| title_full | A New Variant among Newcastle Disease Viruses Isolated in the Democratic Republic of the Congo in 2018 and 2019 |
| title_fullStr | A New Variant among Newcastle Disease Viruses Isolated in the Democratic Republic of the Congo in 2018 and 2019 |
| title_full_unstemmed | A New Variant among Newcastle Disease Viruses Isolated in the Democratic Republic of the Congo in 2018 and 2019 |
| title_short | A New Variant among Newcastle Disease Viruses Isolated in the Democratic Republic of the Congo in 2018 and 2019 |
| title_sort | new variant among newcastle disease viruses isolated in the democratic republic of the congo in 2018 and 2019 |
| topic | new variant Newcastle disease virus chicken outbreak Democratic Republic of the Congo |
| url | https://www.mdpi.com/1999-4915/13/2/151 |
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