Upstream ORFs Prevent MAVS Spontaneous Aggregation and Regulate Innate Immune Homeostasis

Upstream ORFs Prevent MAVS Spontaneous Aggregation and Regulate Innate Immune Homeostasis

Summary: The monomer-to-filament transition of MAVS is essential for the RIG-I/MDA5-mediated antiviral signaling. In quiescent cells, monomeric MAVS is under strict regulation for preventing its spontaneous aggregation, which would result in dysregulated interferon (IFN-α/β) production and autoimmun...

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Bibliographic Details
Main Authors: Yuheng Shi, Jing Wu, Tiansheng Zhong, Wenting Zhu, Guolan She, Hao Tang, Wei Du, Bang-Ce Ye, Nan Qi
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:iScience
Subjects:
Biological Sciences
Cell Biology
Immunology
Molecular Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220302443

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