Association of Serum Level of Substance P with Glycemic Control Indices and Lipids Profile in Non-Obese Type 2 Diabetic Patients
Hyperglycemia and hyperinsulinemia, two common metabolic disorders associated with type 2 diabetes mellitus, are the main causes of metabolic abnormalities that result in a wide range of complications, such as cardiac dysfunction, nephropathy, neuropathy, and retinopathy. Substance-P is an 11-amino...
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2025-02-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
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| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3552 |
| _version_ | 1826803109846843392 |
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| author | Shahad W. Ahmed Shatha Hussein Ali |
| author_facet | Shahad W. Ahmed Shatha Hussein Ali |
| author_sort | Shahad W. Ahmed |
| collection | DOAJ |
| description |
Hyperglycemia and hyperinsulinemia, two common metabolic disorders associated with type 2 diabetes mellitus, are the main causes of metabolic abnormalities that result in a wide range of complications, such as cardiac dysfunction, nephropathy, neuropathy, and retinopathy. Substance-P is an 11-amino acid neuropeptide that is highly conserved and secreted by sensory nerve endings as well as different types of non-neural cells. It was believed that substance P would reduce inflammation triggered on by diabetes, interrupting the development of complications associated with this disease. The current study aims to investigate whether serum levels of substance P are associated with glycemic measures &/or lipids profile in patients with type 2 diabetes mellitus who are not obese. A case-control study involved eighty-five adult subjects (46 males&39females), aged (30-60) years, and was divided into two groups; Group-1: 53 non-obese type 2 diabetic patients (BMI range:18.6-29.9 kg/m2), were selected from the out-patient clinic of The National Centre of Diabetes Treatment & Research, Group-2: 32 individuals were chosen at random from the population as a whole to serve as control Healthy subjects; their ages and sexes were matched to those of the patients. The fasting serum glucose, insulin, homeostatic model assessment-insulin resistance (HOMA-IR), total cholesterol, triglycerides, and haemoglobin A1c (HbA1c) values exhibited significantly higher values in diabetic patients in comparison to controls. (p-value =0.001). Whereas, the serum levels of substance P and high-density lipoprotein were markedly lowered in diabetic individuals relative to the control group. (p-value =0.001). Serum substance P displayed no significant correlations with the studied variables (P˃0.05). In conclusion, serum levels of substance P were lowered significantly in type 2 non-obese diabetic patients compared to healthy controls and displayed non-significant correlations with studied glycemic indices nor with lipids profile.
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| first_indexed | 2025-03-17T01:33:26Z |
| format | Article |
| id | doaj.art-39bf8b507d6b49f5bac053b23e1fca56 |
| institution | Directory Open Access Journal |
| issn | 1683-3597 2521-3512 |
| language | English |
| last_indexed | 2025-03-17T01:33:26Z |
| publishDate | 2025-02-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-39bf8b507d6b49f5bac053b23e1fca562025-02-16T19:32:40ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences1683-35972521-35122025-02-0133(4SI)10.31351/vol33iss(4SI)pp297-303Association of Serum Level of Substance P with Glycemic Control Indices and Lipids Profile in Non-Obese Type 2 Diabetic PatientsShahad W. Ahmed0Shatha Hussein Ali1Department of Clinical Laboratory Science, College of Pharmacy, University of Baghdad, Baghdad, IraqDepartment of Clinical Laboratory Science, College of Pharmacy, University of Baghdad, Baghdad, Iraq Hyperglycemia and hyperinsulinemia, two common metabolic disorders associated with type 2 diabetes mellitus, are the main causes of metabolic abnormalities that result in a wide range of complications, such as cardiac dysfunction, nephropathy, neuropathy, and retinopathy. Substance-P is an 11-amino acid neuropeptide that is highly conserved and secreted by sensory nerve endings as well as different types of non-neural cells. It was believed that substance P would reduce inflammation triggered on by diabetes, interrupting the development of complications associated with this disease. The current study aims to investigate whether serum levels of substance P are associated with glycemic measures &/or lipids profile in patients with type 2 diabetes mellitus who are not obese. A case-control study involved eighty-five adult subjects (46 males&39females), aged (30-60) years, and was divided into two groups; Group-1: 53 non-obese type 2 diabetic patients (BMI range:18.6-29.9 kg/m2), were selected from the out-patient clinic of The National Centre of Diabetes Treatment & Research, Group-2: 32 individuals were chosen at random from the population as a whole to serve as control Healthy subjects; their ages and sexes were matched to those of the patients. The fasting serum glucose, insulin, homeostatic model assessment-insulin resistance (HOMA-IR), total cholesterol, triglycerides, and haemoglobin A1c (HbA1c) values exhibited significantly higher values in diabetic patients in comparison to controls. (p-value =0.001). Whereas, the serum levels of substance P and high-density lipoprotein were markedly lowered in diabetic individuals relative to the control group. (p-value =0.001). Serum substance P displayed no significant correlations with the studied variables (P˃0.05). In conclusion, serum levels of substance P were lowered significantly in type 2 non-obese diabetic patients compared to healthy controls and displayed non-significant correlations with studied glycemic indices nor with lipids profile. https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3552HOMA -IR, Lipid profile, Substance P, Tachykinin, Type 2 Diabetes Mellitus |
| spellingShingle | Shahad W. Ahmed Shatha Hussein Ali Association of Serum Level of Substance P with Glycemic Control Indices and Lipids Profile in Non-Obese Type 2 Diabetic Patients Iraqi Journal of Pharmaceutical Sciences HOMA -IR, Lipid profile, Substance P, Tachykinin, Type 2 Diabetes Mellitus |
| title | Association of Serum Level of Substance P with Glycemic Control Indices and Lipids Profile in Non-Obese Type 2 Diabetic Patients |
| title_full | Association of Serum Level of Substance P with Glycemic Control Indices and Lipids Profile in Non-Obese Type 2 Diabetic Patients |
| title_fullStr | Association of Serum Level of Substance P with Glycemic Control Indices and Lipids Profile in Non-Obese Type 2 Diabetic Patients |
| title_full_unstemmed | Association of Serum Level of Substance P with Glycemic Control Indices and Lipids Profile in Non-Obese Type 2 Diabetic Patients |
| title_short | Association of Serum Level of Substance P with Glycemic Control Indices and Lipids Profile in Non-Obese Type 2 Diabetic Patients |
| title_sort | association of serum level of substance p with glycemic control indices and lipids profile in non obese type 2 diabetic patients |
| topic | HOMA -IR, Lipid profile, Substance P, Tachykinin, Type 2 Diabetes Mellitus |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3552 |
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