Colonic stem cells from normal tissues adjacent to tumor drive inflammation and fibrosis in colorectal cancer

Colonic stem cells from normal tissues adjacent to tumor drive inflammation and fibrosis in colorectal cancer

Abstract Background In colorectal cancer (CRC), the normal tissue adjacent to tumor (NAT) communicates actively with the tumor. Adult stem cells from the colon play a crucial role in the development of the colonic epithelium. In the tumor microenvironment, however, it is unclear what changes have oc...

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Bibliographic Details
Main Authors: Yuanyuan Zhao, Mengmeng Guo, Fuqiang Zhao, Qian Liu, Xia Wang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cell Communication and Signaling
Subjects:
Stem cells
Colorectal cancer
Microenvironment
Fibrosis
Inflammation
Online Access:https://doi.org/10.1186/s12964-023-01140-1

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