Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test
Health-care workers (HCW) are at high risk for SARS-CoV-2 infection and, if asymptomatic, for transmitting the virus to fragile cancer patients. We monitored all asymptomatic HCWs of a cancer institute (94% of all employees agreed to enter the study) with the rapid serological test, VivaDiag<sup&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/6/975 |
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| author | Angelo Virgilio Paradiso Simona De Summa Nicola Silvestris Stefania Tommasi Antonio Tufaro Angela Maria Vittoria Larocca Vincenzo D’Addabbo Donata Raffaele Vito Cafagna Vito Michele Garrisi Giuseppe De Palma |
| author_facet | Angelo Virgilio Paradiso Simona De Summa Nicola Silvestris Stefania Tommasi Antonio Tufaro Angela Maria Vittoria Larocca Vincenzo D’Addabbo Donata Raffaele Vito Cafagna Vito Michele Garrisi Giuseppe De Palma |
| author_sort | Angelo Virgilio Paradiso |
| collection | DOAJ |
| description | Health-care workers (HCW) are at high risk for SARS-CoV-2 infection and, if asymptomatic, for transmitting the virus to fragile cancer patients. We monitored all asymptomatic HCWs of a cancer institute (94% of all employees agreed to enter the study) with the rapid serological test, VivaDiag<sup>TM</sup>, identifying SARS-CoV-2 associated-IgM/IgG. The tests were performed at time 0 (<i>n</i> = 606) and after 14 days (<i>n</i> = 393). Overall, the VivaDiag<sup>TM</sup> results of nine HCWs (1.5%) were positive, with one confirmed to be SARS-CoV-2-positive after oropharyngeal swab testing by RT-PCR. At time 0, all nine cases showed IgM expression while IgG was detected in only one. After 14 days, IgM persisted in all the cases, while IgG became evident in four. A chemiluminescence immunoassay (CLIA) confirmed IgM positivity in 5/13 VivaDiag<sup>TM</sup> positive cases and IgG positivity in 4/5 VivaDiag<sup>TM</sup> positive cases. Our study suggests that the VivaDiag<sup>TM</sup> test can be of help in identifying SARS-CoV-2 infected people in cohorts of subjects with a high prevalence. |
| first_indexed | 2024-03-10T10:57:20Z |
| format | Article |
| id | doaj.art-39c21574fd52454793b00db553505899 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T10:57:20Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-39c21574fd52454793b00db5535058992023-11-21T21:47:17ZengMDPI AGDiagnostics2075-44182021-05-0111697510.3390/diagnostics11060975Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological TestAngelo Virgilio Paradiso0Simona De Summa1Nicola Silvestris2Stefania Tommasi3Antonio Tufaro4Angela Maria Vittoria Larocca5Vincenzo D’Addabbo6Donata Raffaele7Vito Cafagna8Vito Michele Garrisi9Giuseppe De Palma10Scientific Direction, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyMolecular Diagnostics and Pharmacogenetics Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyUnit of Internal Medicine “Guido Baccelli”, Department of Biomedical Sciences and Human Oncology, University of Bari, 70124 Bari, ItalyMolecular Diagnostics and Pharmacogenetics Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyExperimental Oncology and Biobank Management Unit, Institutional BioBank, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyHygiene Unit, University Hospital “Policlinico” of Bari, 70124 Bari, ItalyProfessioni Sanitarie Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyScientific Direction, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyClinical Pathology Laboratory, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyClinical Pathology Laboratory, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyExperimental Oncology and Biobank Management Unit, Institutional BioBank, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyHealth-care workers (HCW) are at high risk for SARS-CoV-2 infection and, if asymptomatic, for transmitting the virus to fragile cancer patients. We monitored all asymptomatic HCWs of a cancer institute (94% of all employees agreed to enter the study) with the rapid serological test, VivaDiag<sup>TM</sup>, identifying SARS-CoV-2 associated-IgM/IgG. The tests were performed at time 0 (<i>n</i> = 606) and after 14 days (<i>n</i> = 393). Overall, the VivaDiag<sup>TM</sup> results of nine HCWs (1.5%) were positive, with one confirmed to be SARS-CoV-2-positive after oropharyngeal swab testing by RT-PCR. At time 0, all nine cases showed IgM expression while IgG was detected in only one. After 14 days, IgM persisted in all the cases, while IgG became evident in four. A chemiluminescence immunoassay (CLIA) confirmed IgM positivity in 5/13 VivaDiag<sup>TM</sup> positive cases and IgG positivity in 4/5 VivaDiag<sup>TM</sup> positive cases. Our study suggests that the VivaDiag<sup>TM</sup> test can be of help in identifying SARS-CoV-2 infected people in cohorts of subjects with a high prevalence.https://www.mdpi.com/2075-4418/11/6/975COVID-19SARS-CoV-2serological testhealth-care workerscancer center |
| spellingShingle | Angelo Virgilio Paradiso Simona De Summa Nicola Silvestris Stefania Tommasi Antonio Tufaro Angela Maria Vittoria Larocca Vincenzo D’Addabbo Donata Raffaele Vito Cafagna Vito Michele Garrisi Giuseppe De Palma Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test Diagnostics COVID-19 SARS-CoV-2 serological test health-care workers cancer center |
| title | Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test |
| title_full | Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test |
| title_fullStr | Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test |
| title_full_unstemmed | Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test |
| title_short | Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test |
| title_sort | prospective observational covid 19 screening and monitoring of asymptomatic cancer center health care workers with a rapid serological test |
| topic | COVID-19 SARS-CoV-2 serological test health-care workers cancer center |
| url | https://www.mdpi.com/2075-4418/11/6/975 |
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