The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD
Abstract Background Physical inactivity due to cachexia and muscle wasting is well recognized as a sign of poor prognosis in chronic obstructive pulmonary disease (COPD). However, there have been no reports on the relationship between trunk muscle measurements and energy expenditure parameters, such...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-021-01621-2 |
| _version_ | 1818430699507548160 |
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| author | Toru Shirahata Hideaki Sato Sanehiro Yogi Kaiji Inoue Mamoru Niitsu Tomoe Akagami Machika Soma Tomohiko Mio Makoto Nagata Satoshi Nakae Yuki Nishida Shigeho Tanaka Fuminori Katsukawa Hidetoshi Nakamura |
| author_facet | Toru Shirahata Hideaki Sato Sanehiro Yogi Kaiji Inoue Mamoru Niitsu Tomoe Akagami Machika Soma Tomohiko Mio Makoto Nagata Satoshi Nakae Yuki Nishida Shigeho Tanaka Fuminori Katsukawa Hidetoshi Nakamura |
| author_sort | Toru Shirahata |
| collection | DOAJ |
| description | Abstract Background Physical inactivity due to cachexia and muscle wasting is well recognized as a sign of poor prognosis in chronic obstructive pulmonary disease (COPD). However, there have been no reports on the relationship between trunk muscle measurements and energy expenditure parameters, such as the total energy expenditure (TEE) and physical activity level (PAL), in COPD. In this study, we investigated the associations of computed tomography (CT)-derived muscle area and density measurements with clinical parameters, including TEE and PAL, in patients with or at risk for COPD, and examined whether these muscle measurements serve as an indicator of TEE and PAL. Methods The study population consisted of 36 male patients with (n = 28, stage 1–4) and at risk for (n = 8) COPD aged over 50 years. TEE was measured by the doubly labeled water method, and PAL was calculated as the TEE/basal metabolic rate estimated by the indirect method. The cross-sectional areas and densities of the pectoralis muscles, rectus abdominis muscles, and erector spinae muscles were measured. We evaluated the relationship between these muscle measurements and clinical outcomes, including body composition, lung function, muscle strength, TEE, and PAL. Results All the muscle areas were significantly associated with TEE, severity of emphysema, and body composition indices such as body mass index, fat-free mass, and trunk muscle mass. All trunk muscle densities were correlated with PAL. The product of the rectus abdominis muscle area and density showed the highest association with TEE (r = 0.732) and PAL (r = 0.578). Several trunk muscle measurements showed significant correlations with maximal inspiratory and expiratory pressures, indicating their roles in respiration. Conclusions CT-derived measurements for trunk muscles are helpful in evaluating physical status and function in patients with or at risk for COPD. Particularly, trunk muscle evaluation may be a useful marker reflecting TEE and PAL. |
| first_indexed | 2024-12-14T15:37:34Z |
| format | Article |
| id | doaj.art-39c2d1a45f68413b81a2d5f4f04a70a9 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-14T15:37:34Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-39c2d1a45f68413b81a2d5f4f04a70a92022-12-21T22:55:41ZengBMCRespiratory Research1465-993X2021-01-0122111210.1186/s12931-021-01621-2The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPDToru Shirahata0Hideaki Sato1Sanehiro Yogi2Kaiji Inoue3Mamoru Niitsu4Tomoe Akagami5Machika Soma6Tomohiko Mio7Makoto Nagata8Satoshi Nakae9Yuki Nishida10Shigeho Tanaka11Fuminori Katsukawa12Hidetoshi Nakamura13Department of Respiratory Medicine, Saitama Medical UniversityDepartment of Respiratory Medicine, Saitama Medical UniversityDepartment of Respiratory Medicine, Saitama Medical UniversityDepartment of Radiology, Saitama Medical UniversityDepartment of Radiology, Saitama Medical UniversityDepartment of Respiratory Medicine, Saitama Medical UniversityDepartment of Respiratory Medicine, Saitama Medical UniversityDepartment of Respiratory Medicine, Saitama Medical UniversityDepartment of Respiratory Medicine, Saitama Medical UniversityDepartment of Nutrition and Metabolism, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and NutritionDepartment of Nutrition and Metabolism, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and NutritionDepartment of Nutrition and Metabolism, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and NutritionSports Medicine Research Center, Keio UniversityDepartment of Respiratory Medicine, Saitama Medical UniversityAbstract Background Physical inactivity due to cachexia and muscle wasting is well recognized as a sign of poor prognosis in chronic obstructive pulmonary disease (COPD). However, there have been no reports on the relationship between trunk muscle measurements and energy expenditure parameters, such as the total energy expenditure (TEE) and physical activity level (PAL), in COPD. In this study, we investigated the associations of computed tomography (CT)-derived muscle area and density measurements with clinical parameters, including TEE and PAL, in patients with or at risk for COPD, and examined whether these muscle measurements serve as an indicator of TEE and PAL. Methods The study population consisted of 36 male patients with (n = 28, stage 1–4) and at risk for (n = 8) COPD aged over 50 years. TEE was measured by the doubly labeled water method, and PAL was calculated as the TEE/basal metabolic rate estimated by the indirect method. The cross-sectional areas and densities of the pectoralis muscles, rectus abdominis muscles, and erector spinae muscles were measured. We evaluated the relationship between these muscle measurements and clinical outcomes, including body composition, lung function, muscle strength, TEE, and PAL. Results All the muscle areas were significantly associated with TEE, severity of emphysema, and body composition indices such as body mass index, fat-free mass, and trunk muscle mass. All trunk muscle densities were correlated with PAL. The product of the rectus abdominis muscle area and density showed the highest association with TEE (r = 0.732) and PAL (r = 0.578). Several trunk muscle measurements showed significant correlations with maximal inspiratory and expiratory pressures, indicating their roles in respiration. Conclusions CT-derived measurements for trunk muscles are helpful in evaluating physical status and function in patients with or at risk for COPD. Particularly, trunk muscle evaluation may be a useful marker reflecting TEE and PAL.https://doi.org/10.1186/s12931-021-01621-2Chronic obstructive pulmonary diseaseComputed tomographyPhysical activity levelTrunk muscleEnergy expenditure |
| spellingShingle | Toru Shirahata Hideaki Sato Sanehiro Yogi Kaiji Inoue Mamoru Niitsu Tomoe Akagami Machika Soma Tomohiko Mio Makoto Nagata Satoshi Nakae Yuki Nishida Shigeho Tanaka Fuminori Katsukawa Hidetoshi Nakamura The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD Respiratory Research Chronic obstructive pulmonary disease Computed tomography Physical activity level Trunk muscle Energy expenditure |
| title | The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD |
| title_full | The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD |
| title_fullStr | The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD |
| title_full_unstemmed | The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD |
| title_short | The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD |
| title_sort | product of trunk muscle area and density on the ct image is a good indicator of energy expenditure in patients with or at risk for copd |
| topic | Chronic obstructive pulmonary disease Computed tomography Physical activity level Trunk muscle Energy expenditure |
| url | https://doi.org/10.1186/s12931-021-01621-2 |
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