Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia
The presence of the signalling lipid Sphingosine 1-phosphate (S1P) in erythrocytes has unclear physiological implications. Here the authors show that the S1P-generating enzyme Sphingosine kinase type 1 and its product S1P play an important role in the red blood cell adaptation to hypoxic environment...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12086 |
| _version_ | 1818980609392902144 |
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| author | Kaiqi Sun Yujin Zhang Angelo D’Alessandro Travis Nemkov Anren Song Hongyu Wu Hong Liu Morayo Adebiyi Aji Huang Yuan E. Wen Mikhail V. Bogdanov Alejandro Vila John O’Brien Rodney E. Kellems William Dowhan Andrew W. Subudhi Sonja Jameson-Van Houten Colleen G. Julian Andrew T. Lovering Martin Safo Kirk C. Hansen Robert C. Roach Yang Xia |
| author_facet | Kaiqi Sun Yujin Zhang Angelo D’Alessandro Travis Nemkov Anren Song Hongyu Wu Hong Liu Morayo Adebiyi Aji Huang Yuan E. Wen Mikhail V. Bogdanov Alejandro Vila John O’Brien Rodney E. Kellems William Dowhan Andrew W. Subudhi Sonja Jameson-Van Houten Colleen G. Julian Andrew T. Lovering Martin Safo Kirk C. Hansen Robert C. Roach Yang Xia |
| author_sort | Kaiqi Sun |
| collection | DOAJ |
| description | The presence of the signalling lipid Sphingosine 1-phosphate (S1P) in erythrocytes has unclear physiological implications. Here the authors show that the S1P-generating enzyme Sphingosine kinase type 1 and its product S1P play an important role in the red blood cell adaptation to hypoxic environments in mice and humans. |
| first_indexed | 2024-12-20T17:18:09Z |
| format | Article |
| id | doaj.art-39c2f9d37bab46039537980e86d2c562 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T17:18:09Z |
| publishDate | 2016-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-39c2f9d37bab46039537980e86d2c5622022-12-21T19:31:56ZengNature PortfolioNature Communications2041-17232016-07-017111310.1038/ncomms12086Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxiaKaiqi Sun0Yujin Zhang1Angelo D’Alessandro2Travis Nemkov3Anren Song4Hongyu Wu5Hong Liu6Morayo Adebiyi7Aji Huang8Yuan E. Wen9Mikhail V. Bogdanov10Alejandro Vila11John O’Brien12Rodney E. Kellems13William Dowhan14Andrew W. Subudhi15Sonja Jameson-Van Houten16Colleen G. Julian17Andrew T. Lovering18Martin Safo19Kirk C. Hansen20Robert C. Roach21Yang Xia22Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonDepartment of Biochemistry and Molecular Genetics, University of Colorado School of MedicineDepartment of Biochemistry and Molecular Genetics, University of Colorado School of MedicineDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonDepartment of Ophthalmology and Visual Science, The University of Texas Health Science Center at HoustonDepartment of Ophthalmology and Visual Science, The University of Texas Health Science Center at HoustonDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonDepartment of Emergency Medicine, Altitude Research Center, University of Colorado School of MedicineDepartment of Emergency Medicine, Altitude Research Center, University of Colorado School of MedicineDepartment of Emergency Medicine, Altitude Research Center, University of Colorado School of MedicineDepartment of Human Physiology, University of OregonDepartment of Medicinal Chemistry, Virginia Commonwealth UniversityDepartment of Biochemistry and Molecular Genetics, University of Colorado School of MedicineDepartment of Emergency Medicine, Altitude Research Center, University of Colorado School of MedicineDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at HoustonThe presence of the signalling lipid Sphingosine 1-phosphate (S1P) in erythrocytes has unclear physiological implications. Here the authors show that the S1P-generating enzyme Sphingosine kinase type 1 and its product S1P play an important role in the red blood cell adaptation to hypoxic environments in mice and humans.https://doi.org/10.1038/ncomms12086 |
| spellingShingle | Kaiqi Sun Yujin Zhang Angelo D’Alessandro Travis Nemkov Anren Song Hongyu Wu Hong Liu Morayo Adebiyi Aji Huang Yuan E. Wen Mikhail V. Bogdanov Alejandro Vila John O’Brien Rodney E. Kellems William Dowhan Andrew W. Subudhi Sonja Jameson-Van Houten Colleen G. Julian Andrew T. Lovering Martin Safo Kirk C. Hansen Robert C. Roach Yang Xia Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia Nature Communications |
| title | Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| title_full | Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| title_fullStr | Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| title_full_unstemmed | Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| title_short | Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia |
| title_sort | sphingosine 1 phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high altitude hypoxia |
| url | https://doi.org/10.1038/ncomms12086 |
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