A Case Report of Differential Diagnosis of Causes of Severe Valvular Heart Disease (Takayasu's Arteritis, Infective Endocarditis and Myxomatous Degeneration) with the Key Role of Histological and PCR Examination
Aortic valve lesion is a common and may have diverse causes, from degenerative, congenital and infectious diseases to autoimmune conditions. We present a rare case of Takayasu arteritis and severe heart lesion due to the myxomatous degeneration of the aortic and mitral valves associated with develop...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2023-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/2855 |
| _version_ | 1826949508914741248 |
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| author | A. S. Pisaryuk E. O. Kotova P. V. Ageev A. Yu. Moiseeva N. M. Povalyaev E. A. Domonova O. Yu. Silveistrova N. S. Tsimbalist Ju. I. Babukhina I. A. Meray P. V. Kakhktsyan A. D. Meshkov A. F. Safarova Zh. D. Kobalava |
| author_facet | A. S. Pisaryuk E. O. Kotova P. V. Ageev A. Yu. Moiseeva N. M. Povalyaev E. A. Domonova O. Yu. Silveistrova N. S. Tsimbalist Ju. I. Babukhina I. A. Meray P. V. Kakhktsyan A. D. Meshkov A. F. Safarova Zh. D. Kobalava |
| author_sort | A. S. Pisaryuk |
| collection | DOAJ |
| description | Aortic valve lesion is a common and may have diverse causes, from degenerative, congenital and infectious diseases to autoimmune conditions. We present a rare case of Takayasu arteritis and severe heart lesion due to the myxomatous degeneration of the aortic and mitral valves associated with development of infective endocarditis (IE) complicated by abscess, fistula, valve perforation and recurrent acute decompensated heart failure in a young female patient. A combined use of histopathological and PCR analyses of valve tissues was critically important for differential diagnosis of the valve lesions, as it made it possible to identify the true cause of the disease. The presence of Takayasu arteritis has played an indirect role by creating conditions for the development of immunosuppression and determining the disease severity and its progression. |
| first_indexed | 2024-03-08T13:59:55Z |
| format | Article |
| id | doaj.art-39c32863b01444e497b208f30fd79542 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2025-02-17T22:14:20Z |
| publishDate | 2023-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-39c32863b01444e497b208f30fd795422024-12-04T11:48:21ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532023-01-0118667668310.20996/1819-6446-2022-12-062081A Case Report of Differential Diagnosis of Causes of Severe Valvular Heart Disease (Takayasu's Arteritis, Infective Endocarditis and Myxomatous Degeneration) with the Key Role of Histological and PCR ExaminationA. S. Pisaryuk0E. O. Kotova1P. V. Ageev2A. Yu. Moiseeva3N. M. Povalyaev4E. A. Domonova5O. Yu. Silveistrova6N. S. Tsimbalist7Ju. I. Babukhina8I. A. Meray9P. V. Kakhktsyan10A. D. Meshkov11A. F. Safarova12Zh. D. Kobalava13Peoples’ Friendship University of Russia (RUDN); City Hospital named after V.V. VinogradovPeoples’ Friendship University of Russia (RUDN); City Hospital named after V.V. VinogradovPeoples’ Friendship University of Russia (RUDN)Peoples’ Friendship University of Russia (RUDN)Peoples’ Friendship University of Russia (RUDN)Federal Budget Institution of Science "Central Research Institute of Epidemiology" of The Federal Service on Customers' Rights Protection and Human Well-being SurveillanceFederal Budget Institution of Science "Central Research Institute of Epidemiology" of The Federal Service on Customers' Rights Protection and Human Well-being SurveillancePeoples’ Friendship University of Russia (RUDN)Federal State Budget Institution «A.N. Bakulev National Medical Research Center of Cardiovascular Surgery» of the Ministry of Health of the Russian Federation (A.N. Bakulev NMRCVS)Peoples’ Friendship University of Russia (RUDN); City Hospital named after V.V. VinogradovFederal State Budget Institution «A.N. Bakulev National Medical Research Center of Cardiovascular Surgery» of the Ministry of Health of the Russian Federation (A.N. Bakulev NMRCVS)Russian Gerontology Research and Clinical CentrePeoples’ Friendship University of Russia (RUDN); City Hospital named after V.V. VinogradovPeoples’ Friendship University of Russia (RUDN); City Hospital named after V.V. VinogradovAortic valve lesion is a common and may have diverse causes, from degenerative, congenital and infectious diseases to autoimmune conditions. We present a rare case of Takayasu arteritis and severe heart lesion due to the myxomatous degeneration of the aortic and mitral valves associated with development of infective endocarditis (IE) complicated by abscess, fistula, valve perforation and recurrent acute decompensated heart failure in a young female patient. A combined use of histopathological and PCR analyses of valve tissues was critically important for differential diagnosis of the valve lesions, as it made it possible to identify the true cause of the disease. The presence of Takayasu arteritis has played an indirect role by creating conditions for the development of immunosuppression and determining the disease severity and its progression.https://www.rpcardio.online/jour/article/view/2855infective endocarditistakayasu arteritisaortic insufficiencypcr-testmyxomatous degenerationhistopathologic examination |
| spellingShingle | A. S. Pisaryuk E. O. Kotova P. V. Ageev A. Yu. Moiseeva N. M. Povalyaev E. A. Domonova O. Yu. Silveistrova N. S. Tsimbalist Ju. I. Babukhina I. A. Meray P. V. Kakhktsyan A. D. Meshkov A. F. Safarova Zh. D. Kobalava A Case Report of Differential Diagnosis of Causes of Severe Valvular Heart Disease (Takayasu's Arteritis, Infective Endocarditis and Myxomatous Degeneration) with the Key Role of Histological and PCR Examination Рациональная фармакотерапия в кардиологии infective endocarditis takayasu arteritis aortic insufficiency pcr-test myxomatous degeneration histopathologic examination |
| title | A Case Report of Differential Diagnosis of Causes of Severe Valvular Heart Disease (Takayasu's Arteritis, Infective Endocarditis and Myxomatous Degeneration) with the Key Role of Histological and PCR Examination |
| title_full | A Case Report of Differential Diagnosis of Causes of Severe Valvular Heart Disease (Takayasu's Arteritis, Infective Endocarditis and Myxomatous Degeneration) with the Key Role of Histological and PCR Examination |
| title_fullStr | A Case Report of Differential Diagnosis of Causes of Severe Valvular Heart Disease (Takayasu's Arteritis, Infective Endocarditis and Myxomatous Degeneration) with the Key Role of Histological and PCR Examination |
| title_full_unstemmed | A Case Report of Differential Diagnosis of Causes of Severe Valvular Heart Disease (Takayasu's Arteritis, Infective Endocarditis and Myxomatous Degeneration) with the Key Role of Histological and PCR Examination |
| title_short | A Case Report of Differential Diagnosis of Causes of Severe Valvular Heart Disease (Takayasu's Arteritis, Infective Endocarditis and Myxomatous Degeneration) with the Key Role of Histological and PCR Examination |
| title_sort | case report of differential diagnosis of causes of severe valvular heart disease takayasu s arteritis infective endocarditis and myxomatous degeneration with the key role of histological and pcr examination |
| topic | infective endocarditis takayasu arteritis aortic insufficiency pcr-test myxomatous degeneration histopathologic examination |
| url | https://www.rpcardio.online/jour/article/view/2855 |
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