Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins
Interferon-induced transmembrane proteins (IFITMs) are a family of proteins which inhibit infections of various enveloped viruses. While their general mechanism of inhibition seems to be non-specific, involving the tightening of membrane structures to prevent fusion between the viral envelope and ce...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/16/2/254 |
| _version_ | 1797296794010386432 |
|---|---|
| author | Thomas Marceau Martine Braibant |
| author_facet | Thomas Marceau Martine Braibant |
| author_sort | Thomas Marceau |
| collection | DOAJ |
| description | Interferon-induced transmembrane proteins (IFITMs) are a family of proteins which inhibit infections of various enveloped viruses. While their general mechanism of inhibition seems to be non-specific, involving the tightening of membrane structures to prevent fusion between the viral envelope and cell membrane, numerous studies have underscored the importance of viral envelope proteins in determining the susceptibility of viruses to IFITMs. Mutations in envelope proteins may lead to viral escape from direct interaction with IFITM proteins or result in indirect resistance by modifying the viral entry pathway, allowing the virus to modulate its exposure to IFITMs. In a broader context, the nature of viral envelope proteins and their interaction with IFITMs can play a crucial role in the context of adaptive immunity, leading to viral envelope proteins that are more susceptible to antibody neutralization. The precise mechanisms underlying these observations remain unclear, and further studies in this field could contribute to a better understanding of how IFITMs control viral infections. |
| first_indexed | 2024-03-07T22:09:57Z |
| format | Article |
| id | doaj.art-39c346d8365746008b2f44e7d6ca624d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-07T22:09:57Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-39c346d8365746008b2f44e7d6ca624d2024-02-23T15:37:37ZengMDPI AGViruses1999-49152024-02-0116225410.3390/v16020254Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM ProteinsThomas Marceau0Martine Braibant1Inserm U1259 MAVIVH, Université de Tours, 37032 Tours, FranceInserm U1259 MAVIVH, Université de Tours, 37032 Tours, FranceInterferon-induced transmembrane proteins (IFITMs) are a family of proteins which inhibit infections of various enveloped viruses. While their general mechanism of inhibition seems to be non-specific, involving the tightening of membrane structures to prevent fusion between the viral envelope and cell membrane, numerous studies have underscored the importance of viral envelope proteins in determining the susceptibility of viruses to IFITMs. Mutations in envelope proteins may lead to viral escape from direct interaction with IFITM proteins or result in indirect resistance by modifying the viral entry pathway, allowing the virus to modulate its exposure to IFITMs. In a broader context, the nature of viral envelope proteins and their interaction with IFITMs can play a crucial role in the context of adaptive immunity, leading to viral envelope proteins that are more susceptible to antibody neutralization. The precise mechanisms underlying these observations remain unclear, and further studies in this field could contribute to a better understanding of how IFITMs control viral infections.https://www.mdpi.com/1999-4915/16/2/254IFITMvirusenveloperestrictionescapesusceptibility |
| spellingShingle | Thomas Marceau Martine Braibant Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins Viruses IFITM virus envelope restriction escape susceptibility |
| title | Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins |
| title_full | Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins |
| title_fullStr | Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins |
| title_full_unstemmed | Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins |
| title_short | Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins |
| title_sort | role of viral envelope proteins in determining susceptibility of viruses to ifitm proteins |
| topic | IFITM virus envelope restriction escape susceptibility |
| url | https://www.mdpi.com/1999-4915/16/2/254 |
| work_keys_str_mv | AT thomasmarceau roleofviralenvelopeproteinsindeterminingsusceptibilityofvirusestoifitmproteins AT martinebraibant roleofviralenvelopeproteinsindeterminingsusceptibilityofvirusestoifitmproteins |