Are Biochemical Markers Important in Predicting Intensive Care Unit Admission and Mortality in COVID-19 Patients?
INTRODUCTION: Many biochemical parameters have been studied in determining the clinical severity of COVID-19 disease. In this study, the effects of NLR, TLR and lymphocyte-CRP ratio on the severity of the disease, the need for intensive care and mortality were investigated in patients diagnosed with...
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| Format: | Article |
| Language: | English |
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Van Yuzuncu Yil University, School of Medicine
2021-07-01
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| Series: | Van Tıp Dergisi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-35219 |
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| author | İhsan Solmaz Songul Araç Burhan Sami Kalın Ömer Faruk Alakuş Süleyman Özçaylak |
| author_facet | İhsan Solmaz Songul Araç Burhan Sami Kalın Ömer Faruk Alakuş Süleyman Özçaylak |
| author_sort | İhsan Solmaz |
| collection | DOAJ |
| description | INTRODUCTION: Many biochemical parameters have been studied in determining the clinical severity of COVID-19 disease. In this study, the effects of NLR, TLR and lymphocyte-CRP ratio on the severity of the disease, the need for intensive care and mortality were investigated in patients diagnosed with COVID-19. METHODS: COVID-19 patients who were followed up in service and intensive care units and whose diagnosis was confirmed by the laboratory at our hospital between August 1th 2020-1th 2020 were retrospectively screened. Demographic data and laboratory values of the patients were recorded from electronic medical records. Multiple logistic regression analysis was performed in terms of mortality and need for intensive care unit treatment. RESULTS: A thousand seven hundred fifty patients were included in the study. 151 (8.62%) patients needed follow-up in the intensive care unit. While there was a significant difference between the survivor and non-survivor patients in terms of age, neutrophil, lymphocyte, CRP, NLR, lymphocyte CRP ratio, TLR, comorbidity and hospitalization days (for all p <0.05). While there was a significant difference among the patient groups who need and do not need intensive care unit hospitalization in terms of in terms of age, radiological involvement, neutrophil, lymphocyte, CRP, NLR, lymphocyte CRP ratio, TLO, comorbidity and hospitalization days (p <0.05 for all). DISCUSSION AND CONCLUSION: Multiple logistic regression analysis was performed to determine risk factors for mortality. In the multiple logistic regression analysis, age, C-Reactive protein, and length of stay hospital were determined as independent risk factors for mortality. |
| first_indexed | 2024-03-09T08:29:34Z |
| format | Article |
| id | doaj.art-39c59c54afb74b52b2b9a4e56c49b7d3 |
| institution | Directory Open Access Journal |
| issn | 2587-0351 |
| language | English |
| last_indexed | 2024-03-09T08:29:34Z |
| publishDate | 2021-07-01 |
| publisher | Van Yuzuncu Yil University, School of Medicine |
| record_format | Article |
| series | Van Tıp Dergisi |
| spelling | doaj.art-39c59c54afb74b52b2b9a4e56c49b7d32023-12-02T20:22:30ZengVan Yuzuncu Yil University, School of MedicineVan Tıp Dergisi2587-03512021-07-0128342843310.5505/vtd.2021.35219VTD-35219Are Biochemical Markers Important in Predicting Intensive Care Unit Admission and Mortality in COVID-19 Patients?İhsan Solmaz0Songul Araç1Burhan Sami Kalın2Ömer Faruk Alakuş3Süleyman Özçaylak4Health Sciences University Diyarbakır Gazi Yaşargil Training and Research Hospital, Department of İnternal Medicine, Diyarbakır,TurkeyUniversity of Health Sciences, Gazi Yaşargil Training and Research Hospital Emergency medicine Clinic, Diyarbakir, TurkeyUniversity of Health Sciences, Gazi Yaşargil Training and Research Hospital Department of İnternal Medicine and intensive care Clinic, Diyarbakir, TurkeyHealth Sciences University Diyarbakır Gazi Yaşargil Training and Research Hospital, Department of İnternal Medicine, Diyarbakır,TurkeyHealth Sciences University Diyarbakır Gazi Yaşargil Training and Research Hospital, Department of İnternal Medicine, Diyarbakır,TurkeyINTRODUCTION: Many biochemical parameters have been studied in determining the clinical severity of COVID-19 disease. In this study, the effects of NLR, TLR and lymphocyte-CRP ratio on the severity of the disease, the need for intensive care and mortality were investigated in patients diagnosed with COVID-19. METHODS: COVID-19 patients who were followed up in service and intensive care units and whose diagnosis was confirmed by the laboratory at our hospital between August 1th 2020-1th 2020 were retrospectively screened. Demographic data and laboratory values of the patients were recorded from electronic medical records. Multiple logistic regression analysis was performed in terms of mortality and need for intensive care unit treatment. RESULTS: A thousand seven hundred fifty patients were included in the study. 151 (8.62%) patients needed follow-up in the intensive care unit. While there was a significant difference between the survivor and non-survivor patients in terms of age, neutrophil, lymphocyte, CRP, NLR, lymphocyte CRP ratio, TLR, comorbidity and hospitalization days (for all p <0.05). While there was a significant difference among the patient groups who need and do not need intensive care unit hospitalization in terms of in terms of age, radiological involvement, neutrophil, lymphocyte, CRP, NLR, lymphocyte CRP ratio, TLO, comorbidity and hospitalization days (p <0.05 for all). DISCUSSION AND CONCLUSION: Multiple logistic regression analysis was performed to determine risk factors for mortality. In the multiple logistic regression analysis, age, C-Reactive protein, and length of stay hospital were determined as independent risk factors for mortality.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-35219covid-19lymphocyte c-reactive protein rationeutrophil-lymphocyte ratioplatelet-lymphocyte ratioage |
| spellingShingle | İhsan Solmaz Songul Araç Burhan Sami Kalın Ömer Faruk Alakuş Süleyman Özçaylak Are Biochemical Markers Important in Predicting Intensive Care Unit Admission and Mortality in COVID-19 Patients? Van Tıp Dergisi covid-19 lymphocyte c-reactive protein ratio neutrophil-lymphocyte ratio platelet-lymphocyte ratio age |
| title | Are Biochemical Markers Important in Predicting Intensive Care Unit Admission and Mortality in COVID-19 Patients? |
| title_full | Are Biochemical Markers Important in Predicting Intensive Care Unit Admission and Mortality in COVID-19 Patients? |
| title_fullStr | Are Biochemical Markers Important in Predicting Intensive Care Unit Admission and Mortality in COVID-19 Patients? |
| title_full_unstemmed | Are Biochemical Markers Important in Predicting Intensive Care Unit Admission and Mortality in COVID-19 Patients? |
| title_short | Are Biochemical Markers Important in Predicting Intensive Care Unit Admission and Mortality in COVID-19 Patients? |
| title_sort | are biochemical markers important in predicting intensive care unit admission and mortality in covid 19 patients |
| topic | covid-19 lymphocyte c-reactive protein ratio neutrophil-lymphocyte ratio platelet-lymphocyte ratio age |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-35219 |
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