Novel multi-target therapeutic potential of the genus Inula: Advances and opportunities for neuroprotection
Ethnopharmacological relevance: The important genus Inula contains more than 100 species and is widespread in the temperate regions of Asia, Africa, and Europe. Numerous Inula species have an ethnobotanical background and are used in Traditional Chinese Medicine (TCM). Aim of the study: This review...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142523000490 |
| _version_ | 1797809075953598464 |
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| author | Marjan Talebi Mona Khoramjouy Afsoon Feizi Zulfıqar Ali Ikhlas A. Khan Neda Alsadat Ayatollahi Seyed Abdulmajid Ayatollahi Mehrdad Faizi |
| author_facet | Marjan Talebi Mona Khoramjouy Afsoon Feizi Zulfıqar Ali Ikhlas A. Khan Neda Alsadat Ayatollahi Seyed Abdulmajid Ayatollahi Mehrdad Faizi |
| author_sort | Marjan Talebi |
| collection | DOAJ |
| description | Ethnopharmacological relevance: The important genus Inula contains more than 100 species and is widespread in the temperate regions of Asia, Africa, and Europe. Numerous Inula species have an ethnobotanical background and are used in Traditional Chinese Medicine (TCM). Aim of the study: This review is a comprehensive study of the more practical therapeutic uses of Inula spp. and their phytochemical compounds in terms of their pharmacological activities, mainly neuroprotective effects. Traditional uses of the genus are described by focusing of TCM. Pharmaceutical, cosmeceutical, and ecological impacts, and their importance in food science, are elaborated upon as well. The pharmacokinetic profile, safety, and toxicity of this genus are also described. Materials and methods: Literature in this review was searched in PubMed, Scopus, Web of Science, and Google Scholar using the keywords “Inula”, “neuro*”, “Alzheimer's disease”, “neuroinflammation”, “seizure”, “epilepsy”, “headache”, “nociception”, “pain”, “insomnia”, “neurotoxicity”, “depression”, “glioblastoma”, and “traumatic brain injury”. Results: This study will provide insight into the neuropharmacological applications of Inula spp. by focusing on the attributed mechanisms of action. The genus Inula has promising protective effects against Alzheimer's disease, neuroinflammation, seizures, insomnia, headaches, neurotoxicity attributed to oxidative damage, depression, nociception, traumatic brain injury, neuromuscular dysfunction, glioblastoma, and primary amoebic meningoencephalitis by targeting various mechanisms and signaling pathways. Conclusion: Due to the acceptable oral bioavailability, blood-brain barrier permeability, and low toxicity of Inula spp. they can be considered promising alternative neuroprotective agents. However more clinical studies are needed in this regard. |
| first_indexed | 2024-03-13T06:47:09Z |
| format | Article |
| id | doaj.art-39c74d83384e417a924e6568b5f13a1d |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-03-13T06:47:09Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-39c74d83384e417a924e6568b5f13a1d2023-06-08T04:20:07ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252023-06-017100263Novel multi-target therapeutic potential of the genus Inula: Advances and opportunities for neuroprotectionMarjan Talebi0Mona Khoramjouy1Afsoon Feizi2Zulfıqar Ali3Ikhlas A. Khan4Neda Alsadat Ayatollahi5Seyed Abdulmajid Ayatollahi6Mehrdad Faizi7Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranFaculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, IranNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USANational Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA; Division of Pharmacognosy, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USAFaculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, PakistanDepartment of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author at: Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author.Ethnopharmacological relevance: The important genus Inula contains more than 100 species and is widespread in the temperate regions of Asia, Africa, and Europe. Numerous Inula species have an ethnobotanical background and are used in Traditional Chinese Medicine (TCM). Aim of the study: This review is a comprehensive study of the more practical therapeutic uses of Inula spp. and their phytochemical compounds in terms of their pharmacological activities, mainly neuroprotective effects. Traditional uses of the genus are described by focusing of TCM. Pharmaceutical, cosmeceutical, and ecological impacts, and their importance in food science, are elaborated upon as well. The pharmacokinetic profile, safety, and toxicity of this genus are also described. Materials and methods: Literature in this review was searched in PubMed, Scopus, Web of Science, and Google Scholar using the keywords “Inula”, “neuro*”, “Alzheimer's disease”, “neuroinflammation”, “seizure”, “epilepsy”, “headache”, “nociception”, “pain”, “insomnia”, “neurotoxicity”, “depression”, “glioblastoma”, and “traumatic brain injury”. Results: This study will provide insight into the neuropharmacological applications of Inula spp. by focusing on the attributed mechanisms of action. The genus Inula has promising protective effects against Alzheimer's disease, neuroinflammation, seizures, insomnia, headaches, neurotoxicity attributed to oxidative damage, depression, nociception, traumatic brain injury, neuromuscular dysfunction, glioblastoma, and primary amoebic meningoencephalitis by targeting various mechanisms and signaling pathways. Conclusion: Due to the acceptable oral bioavailability, blood-brain barrier permeability, and low toxicity of Inula spp. they can be considered promising alternative neuroprotective agents. However more clinical studies are needed in this regard.http://www.sciencedirect.com/science/article/pii/S2667142523000490Neurological diseasesNeurodegenerationAlzheimer's diseaseInulaSesquiterpene lactonesNatural products |
| spellingShingle | Marjan Talebi Mona Khoramjouy Afsoon Feizi Zulfıqar Ali Ikhlas A. Khan Neda Alsadat Ayatollahi Seyed Abdulmajid Ayatollahi Mehrdad Faizi Novel multi-target therapeutic potential of the genus Inula: Advances and opportunities for neuroprotection Pharmacological Research - Modern Chinese Medicine Neurological diseases Neurodegeneration Alzheimer's disease Inula Sesquiterpene lactones Natural products |
| title | Novel multi-target therapeutic potential of the genus Inula: Advances and opportunities for neuroprotection |
| title_full | Novel multi-target therapeutic potential of the genus Inula: Advances and opportunities for neuroprotection |
| title_fullStr | Novel multi-target therapeutic potential of the genus Inula: Advances and opportunities for neuroprotection |
| title_full_unstemmed | Novel multi-target therapeutic potential of the genus Inula: Advances and opportunities for neuroprotection |
| title_short | Novel multi-target therapeutic potential of the genus Inula: Advances and opportunities for neuroprotection |
| title_sort | novel multi target therapeutic potential of the genus inula advances and opportunities for neuroprotection |
| topic | Neurological diseases Neurodegeneration Alzheimer's disease Inula Sesquiterpene lactones Natural products |
| url | http://www.sciencedirect.com/science/article/pii/S2667142523000490 |
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