Histone variants in skeletal myogenesis
Histone variants regulate chromatin accessibility and gene transcription. Given their distinct properties and functions, histone varint substitutions allow for profound alteration of nucleosomal architecture and local chromatin landscape. Skeletal myogenesis driven by the key transcription factor My...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-03-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2020.1795606 |
| _version_ | 1797678876815523840 |
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| author | Nandini Karthik Reshma Taneja |
| author_facet | Nandini Karthik Reshma Taneja |
| author_sort | Nandini Karthik |
| collection | DOAJ |
| description | Histone variants regulate chromatin accessibility and gene transcription. Given their distinct properties and functions, histone varint substitutions allow for profound alteration of nucleosomal architecture and local chromatin landscape. Skeletal myogenesis driven by the key transcription factor MyoD is characterized by precise temporal regulation of myogenic genes. Timed substitution of variants within the nucleosomes provides a powerful means to ensure sequential expression of myogenic genes. Indeed, growing evidence has shown H3.3, H2A.Z, macroH2A, and H1b to be critical for skeletal myogenesis. However, the relative importance of various histone variants and their associated chaperones in myogenesis is not fully appreciated. In this review, we summarize the role that histone variants play in altering chromatin landscape to ensure proper muscle differentiation. The temporal regulation and cross talk between histones variants and their chaperones in conjunction with other forms of epigenetic regulation could be critical to understanding myogenesis and their involvement in myopathies. |
| first_indexed | 2024-03-11T23:06:18Z |
| format | Article |
| id | doaj.art-39c7e68cc8f0447e9d210d3c8fa03b69 |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:06:18Z |
| publishDate | 2021-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-39c7e68cc8f0447e9d210d3c8fa03b692023-09-21T13:09:24ZengTaylor & Francis GroupEpigenetics1559-22941559-23082021-03-0116324326210.1080/15592294.2020.17956061795606Histone variants in skeletal myogenesisNandini Karthik0Reshma Taneja1Yong Loo Lin School of Medicine, National University of SingaporeYong Loo Lin School of Medicine, National University of SingaporeHistone variants regulate chromatin accessibility and gene transcription. Given their distinct properties and functions, histone varint substitutions allow for profound alteration of nucleosomal architecture and local chromatin landscape. Skeletal myogenesis driven by the key transcription factor MyoD is characterized by precise temporal regulation of myogenic genes. Timed substitution of variants within the nucleosomes provides a powerful means to ensure sequential expression of myogenic genes. Indeed, growing evidence has shown H3.3, H2A.Z, macroH2A, and H1b to be critical for skeletal myogenesis. However, the relative importance of various histone variants and their associated chaperones in myogenesis is not fully appreciated. In this review, we summarize the role that histone variants play in altering chromatin landscape to ensure proper muscle differentiation. The temporal regulation and cross talk between histones variants and their chaperones in conjunction with other forms of epigenetic regulation could be critical to understanding myogenesis and their involvement in myopathies.http://dx.doi.org/10.1080/15592294.2020.1795606skeletal myogenesisepigeneticshistone variantsmyopathies |
| spellingShingle | Nandini Karthik Reshma Taneja Histone variants in skeletal myogenesis Epigenetics skeletal myogenesis epigenetics histone variants myopathies |
| title | Histone variants in skeletal myogenesis |
| title_full | Histone variants in skeletal myogenesis |
| title_fullStr | Histone variants in skeletal myogenesis |
| title_full_unstemmed | Histone variants in skeletal myogenesis |
| title_short | Histone variants in skeletal myogenesis |
| title_sort | histone variants in skeletal myogenesis |
| topic | skeletal myogenesis epigenetics histone variants myopathies |
| url | http://dx.doi.org/10.1080/15592294.2020.1795606 |
| work_keys_str_mv | AT nandinikarthik histonevariantsinskeletalmyogenesis AT reshmataneja histonevariantsinskeletalmyogenesis |