Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease
Cheng et al. present differentially expressed extracellular vesicle miRNAs in human clinical samples from patients who suffer from sporadic Creutzfeldt-Jakob disease. This study identifies biomarkers that can be used to detect prion-related diseases, providing insights into drug development for inhi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01868-x |
| _version_ | 1818691945272180736 |
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| author | Lesley Cheng Camelia Quek Xia Li Shayne A. Bellingham Laura J. Ellett Mitch Shambrook Saima Zafar Inga Zerr Victoria A. Lawson Andrew F. Hill |
| author_facet | Lesley Cheng Camelia Quek Xia Li Shayne A. Bellingham Laura J. Ellett Mitch Shambrook Saima Zafar Inga Zerr Victoria A. Lawson Andrew F. Hill |
| author_sort | Lesley Cheng |
| collection | DOAJ |
| description | Cheng et al. present differentially expressed extracellular vesicle miRNAs in human clinical samples from patients who suffer from sporadic Creutzfeldt-Jakob disease. This study identifies biomarkers that can be used to detect prion-related diseases, providing insights into drug development for inhibiting prion infectivity. |
| first_indexed | 2024-12-17T12:49:57Z |
| format | Article |
| id | doaj.art-39c8cfc317f54c2eb8c47b3a23e018f6 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-17T12:49:57Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-39c8cfc317f54c2eb8c47b3a23e018f62022-12-21T21:47:37ZengNature PortfolioCommunications Biology2399-36422021-03-014111210.1038/s42003-021-01868-xDistribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion diseaseLesley Cheng0Camelia Quek1Xia Li2Shayne A. Bellingham3Laura J. Ellett4Mitch Shambrook5Saima Zafar6Inga Zerr7Victoria A. Lawson8Andrew F. Hill9Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe UniversityDepartment of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of MelbourneDepartment of Mathematics and Statistics, La Trobe UniversityDepartment of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of MelbourneDepartment of Pathology, The University of MelbourneDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe UniversityDepartment of Neurology, University Medical Center Göttingen and German Center for Neurodegenerative DiseasesDepartment of Neurology, University Medical Center Göttingen and German Center for Neurodegenerative DiseasesDepartment of Pathology, The University of MelbourneDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe UniversityCheng et al. present differentially expressed extracellular vesicle miRNAs in human clinical samples from patients who suffer from sporadic Creutzfeldt-Jakob disease. This study identifies biomarkers that can be used to detect prion-related diseases, providing insights into drug development for inhibiting prion infectivity.https://doi.org/10.1038/s42003-021-01868-x |
| spellingShingle | Lesley Cheng Camelia Quek Xia Li Shayne A. Bellingham Laura J. Ellett Mitch Shambrook Saima Zafar Inga Zerr Victoria A. Lawson Andrew F. Hill Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease Communications Biology |
| title | Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease |
| title_full | Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease |
| title_fullStr | Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease |
| title_full_unstemmed | Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease |
| title_short | Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease |
| title_sort | distribution of microrna profiles in pre clinical and clinical forms of murine and human prion disease |
| url | https://doi.org/10.1038/s42003-021-01868-x |
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