Itaconate Attenuates Neuroinflammation and Exerts Dopamine Neuroprotection in Parkinson’s Disease through Inhibiting NLRP3 Inflammasome

Itaconate Attenuates Neuroinflammation and Exerts Dopamine Neuroprotection in Parkinson’s Disease through Inhibiting NLRP3 Inflammasome

Parkinson’s disease (PD) is a common age-associated neurodegenerative motor disorder, which is mainly caused by dopaminergic neuron loss in the substantia nigra. This study aimed to evaluate the function and the underlying molecular mechanism of itaconate in PD. PD models were established in vivo an...

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Bibliographic Details
Main Authors: Guoqing Sun, Rui Zhang, Chengxiao Liu, Wenjun Meng, Qi Pang
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Brain Sciences
Subjects:
itaconate
Parkinson’s disease
NLRP3
inflammation
oxidative stress
Online Access:https://www.mdpi.com/2076-3425/12/9/1255

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