DRAMs and autophagy: a family affair
Macroautophagy/autophagy is a conserved catabolic process that delivers intracellular materials to lysosomes for degradation. This process promotes cell survival by maintaining cellular homeostasis and supplying substrates to produce energy during nutrient-deprived conditions. DRAM1 (DNA damage regu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Autophagy Reports |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/27694127.2022.2062965 |
| _version_ | 1797685695200886784 |
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| author | Valentin J. A. Barthet Kevin M. Ryan |
| author_facet | Valentin J. A. Barthet Kevin M. Ryan |
| author_sort | Valentin J. A. Barthet |
| collection | DOAJ |
| description | Macroautophagy/autophagy is a conserved catabolic process that delivers intracellular materials to lysosomes for degradation. This process promotes cell survival by maintaining cellular homeostasis and supplying substrates to produce energy during nutrient-deprived conditions. DRAM1 (DNA damage regulated autophagy modulator 1) is involved in DNA-damage-induced autophagy and belongs to an evolutionarily conserved protein family, which contains five members in human. Our recent study provides the initial characterization of the last two members of the DRAM family in autophagy regulation. Our findings revealed that TMEM150C/DRAM4 (transmembrane protein 150C) and TMEM150A/DRAM5 are nutrient-responsive members of the DRAM family that manifest interconnected roles in modulating the autophagic flux and cell survival under nutrient-deprived conditions. Abbreviations DRAM1: DNA damage regulated autophagy modulator 1 EBSS: Earle’s balanced salt solution MAP1LC3/LC3: Microtubule associated protein 1 light chain 3 |
| first_indexed | 2024-03-12T00:55:02Z |
| format | Article |
| id | doaj.art-39ca68d79311445f8694af162d9edd9a |
| institution | Directory Open Access Journal |
| issn | 2769-4127 |
| language | English |
| last_indexed | 2024-03-12T00:55:02Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autophagy Reports |
| spelling | doaj.art-39ca68d79311445f8694af162d9edd9a2023-09-14T13:24:40ZengTaylor & Francis GroupAutophagy Reports2769-41272022-12-011117017410.1080/27694127.2022.20629652062965DRAMs and autophagy: a family affairValentin J. A. Barthet0Kevin M. Ryan1Cancer Research UK Beatson InstituteCancer Research UK Beatson InstituteMacroautophagy/autophagy is a conserved catabolic process that delivers intracellular materials to lysosomes for degradation. This process promotes cell survival by maintaining cellular homeostasis and supplying substrates to produce energy during nutrient-deprived conditions. DRAM1 (DNA damage regulated autophagy modulator 1) is involved in DNA-damage-induced autophagy and belongs to an evolutionarily conserved protein family, which contains five members in human. Our recent study provides the initial characterization of the last two members of the DRAM family in autophagy regulation. Our findings revealed that TMEM150C/DRAM4 (transmembrane protein 150C) and TMEM150A/DRAM5 are nutrient-responsive members of the DRAM family that manifest interconnected roles in modulating the autophagic flux and cell survival under nutrient-deprived conditions. Abbreviations DRAM1: DNA damage regulated autophagy modulator 1 EBSS: Earle’s balanced salt solution MAP1LC3/LC3: Microtubule associated protein 1 light chain 3http://dx.doi.org/10.1080/27694127.2022.2062965autophagycell survivaldram familydram4dram5nutrient deprivation |
| spellingShingle | Valentin J. A. Barthet Kevin M. Ryan DRAMs and autophagy: a family affair Autophagy Reports autophagy cell survival dram family dram4 dram5 nutrient deprivation |
| title | DRAMs and autophagy: a family affair |
| title_full | DRAMs and autophagy: a family affair |
| title_fullStr | DRAMs and autophagy: a family affair |
| title_full_unstemmed | DRAMs and autophagy: a family affair |
| title_short | DRAMs and autophagy: a family affair |
| title_sort | drams and autophagy a family affair |
| topic | autophagy cell survival dram family dram4 dram5 nutrient deprivation |
| url | http://dx.doi.org/10.1080/27694127.2022.2062965 |
| work_keys_str_mv | AT valentinjabarthet dramsandautophagyafamilyaffair AT kevinmryan dramsandautophagyafamilyaffair |