CB1 receptor antagonist rimonabant protects against chronic intermittent hypoxia-induced renal injury in rats

CB1 receptor antagonist rimonabant protects against chronic intermittent hypoxia-induced renal injury in rats

Abstract Background Obstructive sleep apnoea (OSA) induced chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH). Our study investigate the mechanism underlying CIH-induced renal damage and whether the cannabinoid receptor 1 (CB1R) antagonist rimonabant (Ri) alleviates CIH-in...

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Bibliographic Details
Main Authors:	Li Zhao, Tao Liu, Zhan-jun Dou, Mei-ting Wang, Zi-xuan Hu, Bei Wang
Format:	Article
Language:	English
Published:	BMC 2021-04-01
Series:	BMC Nephrology
Subjects:	Obstructive sleep apnoea Chronic intermittent hypoxia Cannabinoid receptor system 1;renal injury; mitochondrial dynamics Rimonabant
Online Access:	https://doi.org/10.1186/s12882-021-02362-6

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