Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs

Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs

Abstract A comprehensive understanding of the cellular heterogeneity and molecular mechanisms underlying the development, homeostasis, and disease of human intervertebral disks (IVDs) remains challenging. Here, the transcriptomic landscape of 108 108 IVD cells was mapped using single-cell RNA sequen...

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Bibliographic Details
Main Authors: Yibo Gan, Jian He, Jun Zhu, Zhengyang Xu, Zhong Wang, Jing Yan, Ou Hu, Zhijie Bai, Lin Chen, Yangli Xie, Min Jin, Shuo Huang, Bing Liu, Peng Liu
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-021-00163-z

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