Prediction of Allergy by Total Serum IgE Measurements in Infancy: A 10-Year Follow-up
Asthma, allergic rhinitis and atopic dermatitis are multifactorial disorders influenced by various familial and environmental factors. Cord blood IgE levels may be predictive for subsequent allergy onset. Serum IgE assessment has been rarely investigated. This study is aimed at evaluating serum IgE...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2011-05-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X1100900214 |
| _version_ | 1818457770812243968 |
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| author | G. Ciprandi M. De Amici S. Quaglini S. Concaro C. Cerra B. Carugno M. Bosio G.L. Marseglia A. Spinillo M. Stronati R. Moratti |
| author_facet | G. Ciprandi M. De Amici S. Quaglini S. Concaro C. Cerra B. Carugno M. Bosio G.L. Marseglia A. Spinillo M. Stronati R. Moratti |
| author_sort | G. Ciprandi |
| collection | DOAJ |
| description | Asthma, allergic rhinitis and atopic dermatitis are multifactorial disorders influenced by various familial and environmental factors. Cord blood IgE levels may be predictive for subsequent allergy onset. Serum IgE assessment has been rarely investigated. This study is aimed at evaluating serum IgE levels during the first year of life and relating to subsequent allergies. Total serum IgE levels were assessed in 102 newborns in the first days of life (2–3) and then again at 3, 5, 6, 11 and 12 months of age. After ten years, paediatricians and general practitioners caring for these children were tracked through the Local Healthcare Agency (LHA) database and asked about possible allergy of their patients, including transient ones. F Serum IgE increased in allergic infants at 1 year of life. The predictive model was significant. In conclusion, this study demonstrates that serum IgE may be predictive of subsequent allergy onset, preferably if assessed at 1 year of age. |
| first_indexed | 2024-12-14T22:47:51Z |
| format | Article |
| id | doaj.art-39cf877e89714acaab20467364429590 |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-14T22:47:51Z |
| publishDate | 2011-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-39cf877e89714acaab204673644295902022-12-21T22:44:48ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2011-05-01910.1177/1721727X1100900214Prediction of Allergy by Total Serum IgE Measurements in Infancy: A 10-Year Follow-upG. Ciprandi0M. De Amici1S. Quaglini2S. Concaro3C. Cerra4B. Carugno5M. Bosio6G.L. Marseglia7A. Spinillo8M. Stronati9R. Moratti10 Azienda Ospedaliera Universitaria San Martino and University of Genoa, Genova S.C. di Pediatria, Fondazione IRCCS Policlinico S. Matteo-Università degli Studi di Pavia, Pavia Dept. Computer Engineering and Systems Science, University of Pavia, Pavia Dept. Computer Engineering and Systems Science, University of Pavia, Pavia ASL of Pavia, Sistema Informativo Aziendale, Pavia ASL of Pavia, Sistema Informativo Aziendale, Pavia Direzione Sanitaria Aziendale, Fondazione IRCCS Policlinico S. Matteo, Pavia S.C. di Pediatria, Fondazione IRCCS Policlinico S. Matteo-Università degli Studi di Pavia, Pavia Department of Obstetrics and Gynecology, Fondazione IRCCS Policlinico S. Matteo-Università degli Studi di Pavia, Pavia Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico S. Matteo, Pavia Department of Biochemistry, Fondazione IRCCS Policlinico S. Matteo-Università degli Studi di Pavia, Pavia, ItalyAsthma, allergic rhinitis and atopic dermatitis are multifactorial disorders influenced by various familial and environmental factors. Cord blood IgE levels may be predictive for subsequent allergy onset. Serum IgE assessment has been rarely investigated. This study is aimed at evaluating serum IgE levels during the first year of life and relating to subsequent allergies. Total serum IgE levels were assessed in 102 newborns in the first days of life (2–3) and then again at 3, 5, 6, 11 and 12 months of age. After ten years, paediatricians and general practitioners caring for these children were tracked through the Local Healthcare Agency (LHA) database and asked about possible allergy of their patients, including transient ones. F Serum IgE increased in allergic infants at 1 year of life. The predictive model was significant. In conclusion, this study demonstrates that serum IgE may be predictive of subsequent allergy onset, preferably if assessed at 1 year of age.https://doi.org/10.1177/1721727X1100900214 |
| spellingShingle | G. Ciprandi M. De Amici S. Quaglini S. Concaro C. Cerra B. Carugno M. Bosio G.L. Marseglia A. Spinillo M. Stronati R. Moratti Prediction of Allergy by Total Serum IgE Measurements in Infancy: A 10-Year Follow-up European Journal of Inflammation |
| title | Prediction of Allergy by Total Serum IgE Measurements in Infancy: A 10-Year Follow-up |
| title_full | Prediction of Allergy by Total Serum IgE Measurements in Infancy: A 10-Year Follow-up |
| title_fullStr | Prediction of Allergy by Total Serum IgE Measurements in Infancy: A 10-Year Follow-up |
| title_full_unstemmed | Prediction of Allergy by Total Serum IgE Measurements in Infancy: A 10-Year Follow-up |
| title_short | Prediction of Allergy by Total Serum IgE Measurements in Infancy: A 10-Year Follow-up |
| title_sort | prediction of allergy by total serum ige measurements in infancy a 10 year follow up |
| url | https://doi.org/10.1177/1721727X1100900214 |
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