Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes

Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes

2,3,5,6-Tetramethylpyrazine (TMP) as an active ingredient extracted from a traditional Chinese herbal medicine Ligusticum chuanxiong Hort. has been proved to penetrate blood-brain barrier (BBB) and show neuroprotective effects on cerebral ischemia. However, whether TMP could regulate astrocytic reac...

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Bibliographic Details
Main Authors:	Xue-feng Feng, Ming-cong Li, Zi-yue Lin, Man-zhong Li, Yun Lu, Yu-ming Zhuang, Jian-feng Lei, Lei Wang, Hui Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	tetramethylpyrazine ischemic stroke neurogenesis angiogenesis astrocytes neurovascular unit
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2023.1125412/full

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