Synthetic RNA silencing in bacteria - antimicrobial discovery and resistance breaking
The increasing incidence and prevalence of antibiotic resistance in bacteria threatens the antibiotic miracle. Conventional antimicrobial drug development has failed to replace the armamentarium needed to combat this problem, and novel solutions are urgently required. Here we review both natural and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2011-09-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00185/full |
| _version_ | 1811202357596258304 |
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| author | James E.M. Stach Liam eGood |
| author_facet | James E.M. Stach Liam eGood |
| author_sort | James E.M. Stach |
| collection | DOAJ |
| description | The increasing incidence and prevalence of antibiotic resistance in bacteria threatens the antibiotic miracle. Conventional antimicrobial drug development has failed to replace the armamentarium needed to combat this problem, and novel solutions are urgently required. Here we review both natural and synthetic RNA silencing and its potential to provide new antibacterials through improved target selection, evaluation and screening. Furthermore, we focus on synthetic RNA silencers as a novel class of antibacterials and review their unique properties. |
| first_indexed | 2024-04-12T02:38:24Z |
| format | Article |
| id | doaj.art-39d2b43babbc46d29086c2bf2cdf3437 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T02:38:24Z |
| publishDate | 2011-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-39d2b43babbc46d29086c2bf2cdf34372022-12-22T03:51:24ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2011-09-01210.3389/fmicb.2011.0018512242Synthetic RNA silencing in bacteria - antimicrobial discovery and resistance breakingJames E.M. Stach0Liam eGood1University of NewcastleRoyal Veterinary College, University of LondonThe increasing incidence and prevalence of antibiotic resistance in bacteria threatens the antibiotic miracle. Conventional antimicrobial drug development has failed to replace the armamentarium needed to combat this problem, and novel solutions are urgently required. Here we review both natural and synthetic RNA silencing and its potential to provide new antibacterials through improved target selection, evaluation and screening. Furthermore, we focus on synthetic RNA silencers as a novel class of antibacterials and review their unique properties.http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00185/fullDrug DiscoveryGene SilencingResistanceantimicrobialantisensepeptide nucleic acid |
| spellingShingle | James E.M. Stach Liam eGood Synthetic RNA silencing in bacteria - antimicrobial discovery and resistance breaking Frontiers in Microbiology Drug Discovery Gene Silencing Resistance antimicrobial antisense peptide nucleic acid |
| title | Synthetic RNA silencing in bacteria - antimicrobial discovery and resistance breaking |
| title_full | Synthetic RNA silencing in bacteria - antimicrobial discovery and resistance breaking |
| title_fullStr | Synthetic RNA silencing in bacteria - antimicrobial discovery and resistance breaking |
| title_full_unstemmed | Synthetic RNA silencing in bacteria - antimicrobial discovery and resistance breaking |
| title_short | Synthetic RNA silencing in bacteria - antimicrobial discovery and resistance breaking |
| title_sort | synthetic rna silencing in bacteria antimicrobial discovery and resistance breaking |
| topic | Drug Discovery Gene Silencing Resistance antimicrobial antisense peptide nucleic acid |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00185/full |
| work_keys_str_mv | AT jamesemstach syntheticrnasilencinginbacteriaantimicrobialdiscoveryandresistancebreaking AT liamegood syntheticrnasilencinginbacteriaantimicrobialdiscoveryandresistancebreaking |