Stromal Cell Regulation of Intestinal Inflammatory FibrosisSummary
Intestinal inflammatory fibrosis is a severe consequence of inflammatory bowel diseases (IBDs). There is currently no cure for the treatment of intestinal fibrosis in IBD. Although inflammation is necessary for triggering fibrosis, the anti-inflammatory agents used to treat IBD are ineffective in pr...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X24000080 |
| _version_ | 1797258648624300032 |
|---|---|
| author | Wenjing Yang Tianming Yu Yingzi Cong |
| author_facet | Wenjing Yang Tianming Yu Yingzi Cong |
| author_sort | Wenjing Yang |
| collection | DOAJ |
| description | Intestinal inflammatory fibrosis is a severe consequence of inflammatory bowel diseases (IBDs). There is currently no cure for the treatment of intestinal fibrosis in IBD. Although inflammation is necessary for triggering fibrosis, the anti-inflammatory agents used to treat IBD are ineffective in preventing the progression of intestinal fibrosis and stricture formation once initiated, suggesting that inflammatory signals are not the sole drivers of fibrosis progression once it is established. Among multiple mechanisms involved in the initiation and progression of intestinal fibrosis in IBD, stromal cells play critical roles in mediating the process. In this review, we summarize recent progress on how stromal cells regulate intestinal fibrosis in IBD and how they are regulated by focusing on immune regulation and gut microbiota. We also outline the challenges moving forward in the field. |
| first_indexed | 2024-04-24T22:56:53Z |
| format | Article |
| id | doaj.art-39d2c475929b4583b3fc635910b8ec0a |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-04-24T22:56:53Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-39d2c475929b4583b3fc635910b8ec0a2024-03-18T04:34:03ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2024-01-01175703711Stromal Cell Regulation of Intestinal Inflammatory FibrosisSummaryWenjing Yang0Tianming Yu1Yingzi Cong2Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IllinoisDivision of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, IllinoisDivision of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Center for Human Immunobiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Correspondence Address correspondence to: Yingzi Cong, PhD, Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 15-731 Tarry Building, 420 E Superior St, Chicago, Illinois 60611.Intestinal inflammatory fibrosis is a severe consequence of inflammatory bowel diseases (IBDs). There is currently no cure for the treatment of intestinal fibrosis in IBD. Although inflammation is necessary for triggering fibrosis, the anti-inflammatory agents used to treat IBD are ineffective in preventing the progression of intestinal fibrosis and stricture formation once initiated, suggesting that inflammatory signals are not the sole drivers of fibrosis progression once it is established. Among multiple mechanisms involved in the initiation and progression of intestinal fibrosis in IBD, stromal cells play critical roles in mediating the process. In this review, we summarize recent progress on how stromal cells regulate intestinal fibrosis in IBD and how they are regulated by focusing on immune regulation and gut microbiota. We also outline the challenges moving forward in the field.http://www.sciencedirect.com/science/article/pii/S2352345X24000080Stromal cellsInflammatory bowel diseasesIntestinal fibrosisMyofibroblastFibroblasts |
| spellingShingle | Wenjing Yang Tianming Yu Yingzi Cong Stromal Cell Regulation of Intestinal Inflammatory FibrosisSummary Cellular and Molecular Gastroenterology and Hepatology Stromal cells Inflammatory bowel diseases Intestinal fibrosis Myofibroblast Fibroblasts |
| title | Stromal Cell Regulation of Intestinal Inflammatory FibrosisSummary |
| title_full | Stromal Cell Regulation of Intestinal Inflammatory FibrosisSummary |
| title_fullStr | Stromal Cell Regulation of Intestinal Inflammatory FibrosisSummary |
| title_full_unstemmed | Stromal Cell Regulation of Intestinal Inflammatory FibrosisSummary |
| title_short | Stromal Cell Regulation of Intestinal Inflammatory FibrosisSummary |
| title_sort | stromal cell regulation of intestinal inflammatory fibrosissummary |
| topic | Stromal cells Inflammatory bowel diseases Intestinal fibrosis Myofibroblast Fibroblasts |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X24000080 |
| work_keys_str_mv | AT wenjingyang stromalcellregulationofintestinalinflammatoryfibrosissummary AT tianmingyu stromalcellregulationofintestinalinflammatoryfibrosissummary AT yingzicong stromalcellregulationofintestinalinflammatoryfibrosissummary |