| Summary: | The ten most statistically significant estimated glomerular filtration rate (eGFRcrea)-associated loci from genome-wide association studies (GWAs) are tested for associations with chronic kidney disease (CKD) in 208 patients, including dialysis-independent CKD and dialysis-dependent end-stage renal disease (kidney failure). The allele A of intergenic SNP rs2453533 (near <i>GATM</i>) is more frequent in dialysis-independent CKD patients (<i>n</i> = 135, adjusted <i>p</i> = 0.020) but not dialysis-dependent kidney failure patients (<i>n</i> = 73) compared to healthy controls (<i>n</i> = 309). The allele C of intronic SNP rs4293393 (<i>UMOD</i>) is more frequent in healthy controls (adjusted <i>p</i> = 0.042) than in CKD patients. The Allele T of intronic SNP rs9895661 (<i>BCAS3</i>) is associated with decreased eGFRcys (adjusted <i>p</i> = 0.001) and eGFRcrea (adjusted <i>p</i> = 0.017). Our results provide further evidence of a genetic difference between dialysis-independent CKD and dialysis-dependent kidney failure, and add the <i>GATM</i> gene locus to the list of loci associated only with dialysis-independent CKD. <i>GATM</i> risk allele carriers in the dialysis-independent group may have a genetic susceptibility to higher creatinine production rather than increased serum creatinine due to kidney malfunction, and therefore, do not progress to dialysis-dependent kidney failure. When using eGFRcrea for CKD diagnosis, physicians might benefit from information about creatinine-increasing loci.
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