Preventive effects of hydroalcoholic extract of saffron on hematological parameters of experimental asthmatic rats
Objective: Asthma is a chronic inflammatory disease of the respiratory airways distinguished by edema and infiltration of inflammatory immune cells. To test our hypothesis about the anti-inflammatory effect of saffron, we examined effects of Crocus sativus (C. sativus) extract as a prophylactic anti...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2013-05-01
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| Series: | Avicenna Journal of Phytomedicine |
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| Online Access: | http://ajp.mums.ac.ir/pdf_656_7a3b66a4fe5c9e64801286f27464f2f5.html |
| _version_ | 1817967875342729216 |
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| author | Somayyeh Vosooghi Maryam Mahmoudabady Ali Neamati Heydar Aghababa |
| author_facet | Somayyeh Vosooghi Maryam Mahmoudabady Ali Neamati Heydar Aghababa |
| author_sort | Somayyeh Vosooghi |
| collection | DOAJ |
| description | Objective: Asthma is a chronic inflammatory disease of the respiratory airways distinguished by edema and infiltration of inflammatory immune cells. To test our hypothesis about the anti-inflammatory effect of saffron, we examined effects of Crocus sativus (C. sativus) extract as a prophylactic anti-inflammatory agent in sensitized rats. Materials and Methods: To induce experimental asthma, rats were sensitized with injection and inhalation of ovalbumin (OA). Forty male Wistar rats were divided into 5 groups (n=8 for each): control, sensitized (asthma), and sensitized and pretreated with three different concentrations of extract, 50, 100, and 200 mg/kg, 2 times a week (group asthma+50EX, group asthma+100EX, and group asthma+200EX). After 32 days, total white blood cells (WBC) counts, red blood cells (RBC), and platelet counts in blood were examined. Results: Total WBC number and eosinophil and neutrophil percentage in blood were increased, but lymphocyte decreased in sensitized animals compared with those of control group (pConclusion: Our findings indicated that the extract of C. sativus could be useful to prevent asthma as an anti-inflammatory treatment. |
| first_indexed | 2024-04-12T13:29:07Z |
| format | Article |
| id | doaj.art-39d69a8909744ef48498cad6b0d66ba1 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-12T13:29:07Z |
| publishDate | 2013-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-39d69a8909744ef48498cad6b0d66ba12022-12-22T03:31:14ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492013-05-0133279287656Preventive effects of hydroalcoholic extract of saffron on hematological parameters of experimental asthmatic ratsSomayyeh Vosooghi0Maryam Mahmoudabady1Ali Neamati2Heydar Aghababa3Department of Biology, Payame Noor University, Boshruyeh, South Khorasan, I. R. IranApplied Physiology Research Centre and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. IranDepartment of Biology, Faculty of Science, Mashhad Branch, Islamic Azad University, Mashhad, I. R. IranDepartment of Biology, Faculty of Science, Arsanjan Branch, Islamic Azad University, I. R. IranObjective: Asthma is a chronic inflammatory disease of the respiratory airways distinguished by edema and infiltration of inflammatory immune cells. To test our hypothesis about the anti-inflammatory effect of saffron, we examined effects of Crocus sativus (C. sativus) extract as a prophylactic anti-inflammatory agent in sensitized rats. Materials and Methods: To induce experimental asthma, rats were sensitized with injection and inhalation of ovalbumin (OA). Forty male Wistar rats were divided into 5 groups (n=8 for each): control, sensitized (asthma), and sensitized and pretreated with three different concentrations of extract, 50, 100, and 200 mg/kg, 2 times a week (group asthma+50EX, group asthma+100EX, and group asthma+200EX). After 32 days, total white blood cells (WBC) counts, red blood cells (RBC), and platelet counts in blood were examined. Results: Total WBC number and eosinophil and neutrophil percentage in blood were increased, but lymphocyte decreased in sensitized animals compared with those of control group (pConclusion: Our findings indicated that the extract of C. sativus could be useful to prevent asthma as an anti-inflammatory treatment.http://ajp.mums.ac.ir/pdf_656_7a3b66a4fe5c9e64801286f27464f2f5.htmlasthmaCrocus sativusInflammationRatsensitizationWBC |
| spellingShingle | Somayyeh Vosooghi Maryam Mahmoudabady Ali Neamati Heydar Aghababa Preventive effects of hydroalcoholic extract of saffron on hematological parameters of experimental asthmatic rats Avicenna Journal of Phytomedicine asthma Crocus sativus Inflammation Rat sensitization WBC |
| title | Preventive effects of hydroalcoholic extract of saffron on hematological parameters of experimental asthmatic rats |
| title_full | Preventive effects of hydroalcoholic extract of saffron on hematological parameters of experimental asthmatic rats |
| title_fullStr | Preventive effects of hydroalcoholic extract of saffron on hematological parameters of experimental asthmatic rats |
| title_full_unstemmed | Preventive effects of hydroalcoholic extract of saffron on hematological parameters of experimental asthmatic rats |
| title_short | Preventive effects of hydroalcoholic extract of saffron on hematological parameters of experimental asthmatic rats |
| title_sort | preventive effects of hydroalcoholic extract of saffron on hematological parameters of experimental asthmatic rats |
| topic | asthma Crocus sativus Inflammation Rat sensitization WBC |
| url | http://ajp.mums.ac.ir/pdf_656_7a3b66a4fe5c9e64801286f27464f2f5.html |
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