Can Selenium Reduce the Susceptibility and Severity of SARS-CoV-2?—A Comprehensive Review
The SARS-CoV-2 infection is a highly contagious viral infection, which has claimed millions of lives in the last two years. The infection can cause acute respiratory distress, myocarditis, and systemic inflammatory response in severe cases. The interaction of the viral spike protein with the angiote...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/4809 |
| _version_ | 1797504541119217664 |
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| author | Muhammed Majeed Kalyanam Nagabhushanam Priji Prakasan Lakshmi Mundkur |
| author_facet | Muhammed Majeed Kalyanam Nagabhushanam Priji Prakasan Lakshmi Mundkur |
| author_sort | Muhammed Majeed |
| collection | DOAJ |
| description | The SARS-CoV-2 infection is a highly contagious viral infection, which has claimed millions of lives in the last two years. The infection can cause acute respiratory distress, myocarditis, and systemic inflammatory response in severe cases. The interaction of the viral spike protein with the angiotensin-converting enzyme in various tissues causes damage to vital organs and tissues, leading to complications in the post-infection period. Vaccines and antiviral drugs have improved patient response to the infection, but the long-term effect on vital organs is still unknown. Investigations are now focused on supportive nutrient therapies, which can mitigate the susceptibility as well as the long-term complications of COVID-19. Selenium is one such micronutrient that plays a vital role in preventing oxidative stress induced by the virus. Further, selenium is important for effective immune response, controlling systemic inflammation, and maintain overall health of humans. We examine the role of selenium in various aspects of SARS-CoV-2 infection and address the importance of selenium supplementation in reducing the susceptibility and severity of infection in this review. |
| first_indexed | 2024-03-10T04:06:02Z |
| format | Article |
| id | doaj.art-39d6ce336a2a4d76a6a97186bb79c123 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:06:02Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-39d6ce336a2a4d76a6a97186bb79c1232023-11-23T08:22:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01239480910.3390/ijms23094809Can Selenium Reduce the Susceptibility and Severity of SARS-CoV-2?—A Comprehensive ReviewMuhammed Majeed0Kalyanam Nagabhushanam1Priji Prakasan2Lakshmi Mundkur3Sami-Sabinsa Group Limited, 19/1&19/2, I Main, II Phase, Peenya Industrial Area, Bangalore 560-058, Karnataka, IndiaSabinsa Corporation, 20 Lake Drive, East Windsor, NJ 08520, USASami-Sabinsa Group Limited, 19/1&19/2, I Main, II Phase, Peenya Industrial Area, Bangalore 560-058, Karnataka, IndiaSami-Sabinsa Group Limited, 19/1&19/2, I Main, II Phase, Peenya Industrial Area, Bangalore 560-058, Karnataka, IndiaThe SARS-CoV-2 infection is a highly contagious viral infection, which has claimed millions of lives in the last two years. The infection can cause acute respiratory distress, myocarditis, and systemic inflammatory response in severe cases. The interaction of the viral spike protein with the angiotensin-converting enzyme in various tissues causes damage to vital organs and tissues, leading to complications in the post-infection period. Vaccines and antiviral drugs have improved patient response to the infection, but the long-term effect on vital organs is still unknown. Investigations are now focused on supportive nutrient therapies, which can mitigate the susceptibility as well as the long-term complications of COVID-19. Selenium is one such micronutrient that plays a vital role in preventing oxidative stress induced by the virus. Further, selenium is important for effective immune response, controlling systemic inflammation, and maintain overall health of humans. We examine the role of selenium in various aspects of SARS-CoV-2 infection and address the importance of selenium supplementation in reducing the susceptibility and severity of infection in this review.https://www.mdpi.com/1422-0067/23/9/4809seleniummicronutrientSARS-CoV-2immunityinflammationoxidative stress |
| spellingShingle | Muhammed Majeed Kalyanam Nagabhushanam Priji Prakasan Lakshmi Mundkur Can Selenium Reduce the Susceptibility and Severity of SARS-CoV-2?—A Comprehensive Review International Journal of Molecular Sciences selenium micronutrient SARS-CoV-2 immunity inflammation oxidative stress |
| title | Can Selenium Reduce the Susceptibility and Severity of SARS-CoV-2?—A Comprehensive Review |
| title_full | Can Selenium Reduce the Susceptibility and Severity of SARS-CoV-2?—A Comprehensive Review |
| title_fullStr | Can Selenium Reduce the Susceptibility and Severity of SARS-CoV-2?—A Comprehensive Review |
| title_full_unstemmed | Can Selenium Reduce the Susceptibility and Severity of SARS-CoV-2?—A Comprehensive Review |
| title_short | Can Selenium Reduce the Susceptibility and Severity of SARS-CoV-2?—A Comprehensive Review |
| title_sort | can selenium reduce the susceptibility and severity of sars cov 2 a comprehensive review |
| topic | selenium micronutrient SARS-CoV-2 immunity inflammation oxidative stress |
| url | https://www.mdpi.com/1422-0067/23/9/4809 |
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