Nutcracker syndrome combined with immunoglobulin A nephropathy: two case reports
Nutcracker syndrome (NCS) is a disease caused by compression of the left renal vein between the superior mesenteric artery and the abdominal aorta. Immunoglobulin A (IgA) nephropathy (IgAN) is characterized by the predominance of IgA deposits in the glomerular mesangial area. Hematuria and proteinur...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Nephrology
2023-12-01
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| Series: | Childhood Kidney Diseases |
| Subjects: | |
| Online Access: | http://www.chikd.org/upload/ckd-23-013.pdf |
| _version_ | 1827246853560729600 |
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| author | So Hyun Ki Min Hwa Son Eujin Park Hyung Eun Yim |
| author_facet | So Hyun Ki Min Hwa Son Eujin Park Hyung Eun Yim |
| author_sort | So Hyun Ki |
| collection | DOAJ |
| description | Nutcracker syndrome (NCS) is a disease caused by compression of the left renal vein between the superior mesenteric artery and the abdominal aorta. Immunoglobulin A (IgA) nephropathy (IgAN) is characterized by the predominance of IgA deposits in the glomerular mesangial area. Hematuria and proteinuria can be present in both diseases, and some patients can be concurrently diagnosed with NCS and IgAN; however, a causal relationship between the two diseases has not yet been clarified. Here, we report two pediatric cases of NCS combined with IgAN. The first patient presenting with microscopic hematuria and proteinuria was diagnosed with NCS at the initial visit, and the second patient was later diagnosed with NCS when proteinuria worsened. Both patients were diagnosed with IgAN based on kidney biopsy findings and treated with angiotensin-converting enzyme inhibitors and immunosuppressants. A high index of suspicion and timely imaging or biopsy are essential for the proper management of NCS combined with glomerulopathy. |
| first_indexed | 2024-03-08T01:58:39Z |
| format | Article |
| id | doaj.art-39d80e8ce0b448108f9446fd8e486262 |
| institution | Directory Open Access Journal |
| issn | 2384-0242 2384-0250 |
| language | English |
| last_indexed | 2025-03-21T23:06:33Z |
| publishDate | 2023-12-01 |
| publisher | Korean Society of Pediatric Nephrology |
| record_format | Article |
| series | Childhood Kidney Diseases |
| spelling | doaj.art-39d80e8ce0b448108f9446fd8e4862622024-05-22T05:33:17ZengKorean Society of Pediatric NephrologyChildhood Kidney Diseases2384-02422384-02502023-12-0127213313810.3339/ckd.23.013789Nutcracker syndrome combined with immunoglobulin A nephropathy: two case reportsSo Hyun Ki0Min Hwa Son1Eujin Park2Hyung Eun Yim3 Department of Pediatrics, Korea University Guro Hospital, Seoul, Republic of Korea Department of Pediatrics, Korea University Ansan Hospital, Ansan, Republic of Korea Department of Pediatrics, Korea University Guro Hospital, Seoul, Republic of Korea Department of Pediatrics, Korea University Ansan Hospital, Ansan, Republic of KoreaNutcracker syndrome (NCS) is a disease caused by compression of the left renal vein between the superior mesenteric artery and the abdominal aorta. Immunoglobulin A (IgA) nephropathy (IgAN) is characterized by the predominance of IgA deposits in the glomerular mesangial area. Hematuria and proteinuria can be present in both diseases, and some patients can be concurrently diagnosed with NCS and IgAN; however, a causal relationship between the two diseases has not yet been clarified. Here, we report two pediatric cases of NCS combined with IgAN. The first patient presenting with microscopic hematuria and proteinuria was diagnosed with NCS at the initial visit, and the second patient was later diagnosed with NCS when proteinuria worsened. Both patients were diagnosed with IgAN based on kidney biopsy findings and treated with angiotensin-converting enzyme inhibitors and immunosuppressants. A high index of suspicion and timely imaging or biopsy are essential for the proper management of NCS combined with glomerulopathy.http://www.chikd.org/upload/ckd-23-013.pdfcase reportsglomerulonephritisimmunoglobulin arenal nutcracker syndrome |
| spellingShingle | So Hyun Ki Min Hwa Son Eujin Park Hyung Eun Yim Nutcracker syndrome combined with immunoglobulin A nephropathy: two case reports Childhood Kidney Diseases case reports glomerulonephritis immunoglobulin a renal nutcracker syndrome |
| title | Nutcracker syndrome combined with immunoglobulin A nephropathy: two case reports |
| title_full | Nutcracker syndrome combined with immunoglobulin A nephropathy: two case reports |
| title_fullStr | Nutcracker syndrome combined with immunoglobulin A nephropathy: two case reports |
| title_full_unstemmed | Nutcracker syndrome combined with immunoglobulin A nephropathy: two case reports |
| title_short | Nutcracker syndrome combined with immunoglobulin A nephropathy: two case reports |
| title_sort | nutcracker syndrome combined with immunoglobulin a nephropathy two case reports |
| topic | case reports glomerulonephritis immunoglobulin a renal nutcracker syndrome |
| url | http://www.chikd.org/upload/ckd-23-013.pdf |
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