| Summary: | This study sought to examine the relationship between knowledge, attitude, and acceptance of Coronavirus Disease 2019 (COVID-19) vaccine among students in selected universities in Nigeria. An anonymous survey was conducted online among Nigeria students. The questionnaire collected demographic characteristics, knowledge, attitudes, and acceptance of vaccines among respondents during the COVID-19 pandemic. Data were analyzed using descriptive and inferential statistic. Of the 521 participants surveyed, 74 (14.2) stated that they have already received COVID-19 vaccination, whereas 286 (54.9%) intend to be vaccinated as soon as the vaccine becomes available. Negative attitude toward COVID-19 vaccination has an inverse, very weak, and significant relationship with intent to vaccinate (r = −0.125, N = 521, p < 0.01). However, knowledge of COVID-19 vaccines was significantly related with intent to vaccinate (r = 0.130, N = 521, p < 0.01). The study concluded that knowledge and attitude of students toward vaccines are highly essential for their acceptance. Results suggest that vaccine acceptability may be increased if students’ knowledge of vaccines is increased, and attitudes toward vaccination are improved by addressing the respondents’ worries about vaccines’ unforeseen effects, and changing their general mistrust of the benefits of vaccines.
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