Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications
Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.01021/full |
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| author | Javad Sharifi-Rad Youssef El Rayess Alain Abi Rizk Carmen Sadaka Raviella Zgheib Wissam Zam Simona Sestito Simona Rapposelli Simona Rapposelli Katarzyna Neffe-Skocińska Dorota Zielińska Bahare Salehi Bahare Salehi William N. Setzer William N. Setzer Noura S. Dosoky Yasaman Taheri Yasaman Taheri Marc El Beyrouthy Miquel Martorell Miquel Martorell Elise Adrian Ostrander Hafiz Ansar Rasul Suleria William C. Cho Alfred Maroyi Natália Martins Natália Martins |
| author_facet | Javad Sharifi-Rad Youssef El Rayess Alain Abi Rizk Carmen Sadaka Raviella Zgheib Wissam Zam Simona Sestito Simona Rapposelli Simona Rapposelli Katarzyna Neffe-Skocińska Dorota Zielińska Bahare Salehi Bahare Salehi William N. Setzer William N. Setzer Noura S. Dosoky Yasaman Taheri Yasaman Taheri Marc El Beyrouthy Miquel Martorell Miquel Martorell Elise Adrian Ostrander Hafiz Ansar Rasul Suleria William C. Cho Alfred Maroyi Natália Martins Natália Martins |
| author_sort | Javad Sharifi-Rad |
| collection | DOAJ |
| description | Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of curcumin applications for food and biotechnological industries, and on health promotion and disease prevention, with particular emphasis on its antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, and cardioprotective effects. Bioavailability, bioefficacy and safety features, side effects, and quality parameters of curcumin are also addressed. Finally, curcumin’s multidimensional applications, food attractiveness optimization, agro-industrial procedures to offset its instability and low bioavailability, health concerns, and upcoming strategies for clinical application are also covered. |
| first_indexed | 2024-12-10T16:20:47Z |
| format | Article |
| id | doaj.art-39d9df3526e6473fa3ea7f24da0ab324 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T16:20:47Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-39d9df3526e6473fa3ea7f24da0ab3242022-12-22T01:41:49ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-09-011110.3389/fphar.2020.01021550909Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal ApplicationsJavad Sharifi-Rad0Youssef El Rayess1Alain Abi Rizk2Carmen Sadaka3Raviella Zgheib4Wissam Zam5Simona Sestito6Simona Rapposelli7Simona Rapposelli8Katarzyna Neffe-Skocińska9Dorota Zielińska10Bahare Salehi11Bahare Salehi12William N. Setzer13William N. Setzer14Noura S. Dosoky15Yasaman Taheri16Yasaman Taheri17Marc El Beyrouthy18Miquel Martorell19Miquel Martorell20Elise Adrian Ostrander21Hafiz Ansar Rasul Suleria22William C. Cho23Alfred Maroyi24Natália Martins25Natália Martins26Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, IranDepartment of Agriculture and Food Engineering, School of Engineering, Holy Spirit University of Kasli, Jounieh, LebanonDepartment of Agriculture and Food Engineering, School of Engineering, Holy Spirit University of Kasli, Jounieh, LebanonFaculty of Medicine, American University of Beirut, Beirut, LebanonInstitut Jean-Pierre Bourgin, AgroParisTech, INRA, Université Paris-Saclay, Versailles, FranceDepartment of Analytical and Food Chemistry, Faculty of Pharmacy, Al-Andalus University for Medical Sciences, Tartous, SyriaDepartment of Pharmacy, University of Pisa, Pisa, ItalyDepartment of Pharmacy, University of Pisa, Pisa, ItalyInterdepartmental Research Centre for Biology and Pathology of Aging, University of Pisa, Pisa, ItalyInstitute of Human Nutrition Sciences, Warsaw University of Life Sciences, Warszawa, PolandInstitute of Human Nutrition Sciences, Warsaw University of Life Sciences, Warszawa, PolandNoncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran0Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran1Aromatic Plant Research Center, Lehi, UT, United States2Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, United States1Aromatic Plant Research Center, Lehi, UT, United States3Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran4Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Agriculture and Food Engineering, School of Engineering, Holy Spirit University of Kasli, Jounieh, Lebanon5Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile6Unidad de Desarrollo Tecnológico, UDT, Universidad de Concepción, Concepción, Chile7Medical Illustration, Kendall College of Art and Design, Ferris State University, Grand Rapids, MI, United States8Department of Agriculture and Food Systems, The University of Melbourne, Melbourne, VIC, Australia9Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong0Department of Botany, University of Fort Hare, Alice, South Africa1Faculty of Medicine, University of Porto, Porto, Portugal2Institute for Research and Innovation in Health (i3S), University of Porto, Porto, PortugalCurcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of curcumin applications for food and biotechnological industries, and on health promotion and disease prevention, with particular emphasis on its antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, and cardioprotective effects. Bioavailability, bioefficacy and safety features, side effects, and quality parameters of curcumin are also addressed. Finally, curcumin’s multidimensional applications, food attractiveness optimization, agro-industrial procedures to offset its instability and low bioavailability, health concerns, and upcoming strategies for clinical application are also covered.https://www.frontiersin.org/article/10.3389/fphar.2020.01021/fullCurcuma longa L.curcumaturmericspicecurcuminoidspharmacological effects |
| spellingShingle | Javad Sharifi-Rad Youssef El Rayess Alain Abi Rizk Carmen Sadaka Raviella Zgheib Wissam Zam Simona Sestito Simona Rapposelli Simona Rapposelli Katarzyna Neffe-Skocińska Dorota Zielińska Bahare Salehi Bahare Salehi William N. Setzer William N. Setzer Noura S. Dosoky Yasaman Taheri Yasaman Taheri Marc El Beyrouthy Miquel Martorell Miquel Martorell Elise Adrian Ostrander Hafiz Ansar Rasul Suleria William C. Cho Alfred Maroyi Natália Martins Natália Martins Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications Frontiers in Pharmacology Curcuma longa L. curcuma turmeric spice curcuminoids pharmacological effects |
| title | Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications |
| title_full | Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications |
| title_fullStr | Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications |
| title_full_unstemmed | Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications |
| title_short | Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications |
| title_sort | turmeric and its major compound curcumin on health bioactive effects and safety profiles for food pharmaceutical biotechnological and medicinal applications |
| topic | Curcuma longa L. curcuma turmeric spice curcuminoids pharmacological effects |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.01021/full |
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