Micromotor‐Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy
Abstract Sepsis is a highly heterogeneous syndrome normally characterized by bacterial infection and dysregulated systemic inflammatory response that leads to multiple organ failure and death. Single anti‐inflammation or anti‐infection treatment exhibits limited survival benefit for severe cases. He...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202303759 |
| _version_ | 1797465092848091136 |
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| author | Yanzhen Song Ruotian Zhang Hanfeng Qin Wenxin Xu Jia Sun Jiamiao Jiang Yicheng Ye Junbin Gao Huaan Li Weichang Huang Kun Liu Yunrui Hu Fei Peng Yingfeng Tu |
| author_facet | Yanzhen Song Ruotian Zhang Hanfeng Qin Wenxin Xu Jia Sun Jiamiao Jiang Yicheng Ye Junbin Gao Huaan Li Weichang Huang Kun Liu Yunrui Hu Fei Peng Yingfeng Tu |
| author_sort | Yanzhen Song |
| collection | DOAJ |
| description | Abstract Sepsis is a highly heterogeneous syndrome normally characterized by bacterial infection and dysregulated systemic inflammatory response that leads to multiple organ failure and death. Single anti‐inflammation or anti‐infection treatment exhibits limited survival benefit for severe cases. Here a biodegradable tobramycin‐loaded magnesium micromotor (Mg‐Tob motor) is successfully developed as a potential hydrogen generator and active antibiotic deliverer for synergistic therapy of sepsis. The peritoneal fluid of septic mouse provides an applicable space for Mg‐water reaction. Hydrogen generated sustainably and controllably from the motor interface propels the motion to achieve active drug delivery along with attenuating hyperinflammation. The developed Mg‐Tob motor demonstrates efficient protection from anti‐inflammatory and antibacterial activity both in vitro and in vivo. Importantly, it prevents multiple organ failure and significantly improves the survival rate up to 87.5% in a high‐grade sepsis model with no survival, whereas only about half of mice survive with the individual therapies. This micromotor displays the superior therapeutic effect of synergistic hydrogen‐chemical therapy against sepsis, thus holding great promise to be an innovative and translational drug delivery system to treat sepsis or other inflammation‐related diseases in the near future. |
| first_indexed | 2024-03-09T18:16:30Z |
| format | Article |
| id | doaj.art-39dd96dbf5ef4d57a8dccb3842fc154e |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-09T18:16:30Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-39dd96dbf5ef4d57a8dccb3842fc154e2023-11-24T08:40:29ZengWileyAdvanced Science2198-38442023-11-011033n/an/a10.1002/advs.202303759Micromotor‐Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis TherapyYanzhen Song0Ruotian Zhang1Hanfeng Qin2Wenxin Xu3Jia Sun4Jiamiao Jiang5Yicheng Ye6Junbin Gao7Huaan Li8Weichang Huang9Kun Liu10Yunrui Hu11Fei Peng12Yingfeng Tu13NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaSchool of Materials Science and Engineering Sun Yat‐Sen University Guangzhou 510275 ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 ChinaAbstract Sepsis is a highly heterogeneous syndrome normally characterized by bacterial infection and dysregulated systemic inflammatory response that leads to multiple organ failure and death. Single anti‐inflammation or anti‐infection treatment exhibits limited survival benefit for severe cases. Here a biodegradable tobramycin‐loaded magnesium micromotor (Mg‐Tob motor) is successfully developed as a potential hydrogen generator and active antibiotic deliverer for synergistic therapy of sepsis. The peritoneal fluid of septic mouse provides an applicable space for Mg‐water reaction. Hydrogen generated sustainably and controllably from the motor interface propels the motion to achieve active drug delivery along with attenuating hyperinflammation. The developed Mg‐Tob motor demonstrates efficient protection from anti‐inflammatory and antibacterial activity both in vitro and in vivo. Importantly, it prevents multiple organ failure and significantly improves the survival rate up to 87.5% in a high‐grade sepsis model with no survival, whereas only about half of mice survive with the individual therapies. This micromotor displays the superior therapeutic effect of synergistic hydrogen‐chemical therapy against sepsis, thus holding great promise to be an innovative and translational drug delivery system to treat sepsis or other inflammation‐related diseases in the near future.https://doi.org/10.1002/advs.202303759drug deliveryhydrogenmicromotorsepsissynergistic therapy |
| spellingShingle | Yanzhen Song Ruotian Zhang Hanfeng Qin Wenxin Xu Jia Sun Jiamiao Jiang Yicheng Ye Junbin Gao Huaan Li Weichang Huang Kun Liu Yunrui Hu Fei Peng Yingfeng Tu Micromotor‐Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy Advanced Science drug delivery hydrogen micromotor sepsis synergistic therapy |
| title | Micromotor‐Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy |
| title_full | Micromotor‐Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy |
| title_fullStr | Micromotor‐Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy |
| title_full_unstemmed | Micromotor‐Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy |
| title_short | Micromotor‐Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy |
| title_sort | micromotor enabled active hydrogen and tobramycin delivery for synergistic sepsis therapy |
| topic | drug delivery hydrogen micromotor sepsis synergistic therapy |
| url | https://doi.org/10.1002/advs.202303759 |
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