Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation

Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation

Abstract Brain vascular integrity is critical for brain health, and its disruption is implicated in many brain pathologies, including psychiatric disorders. Brain-vascular barriers are a complex cellular landscape composed of endothelial, glial, mural, and immune cells. Yet currently, little is know...

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Bibliographic Details
Main Authors: Joshua D. Samuels, Madison L. Lotstein, Michael L. Lehmann, Abdel G. Elkahloun, Subhadra Banerjee, Miles Herkenham
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Neuroinflammation
Subjects:
Single-cell RNA sequencing
Cerebrovasculature
Psychosocial stress
Vascular repair
Immune activation
Online Access:https://doi.org/10.1186/s12974-023-02827-5

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