Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells

Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells

Activation of the nuclear factor erythroid 2–related factor 2 (Nrf2) pathway is critical for vascular endothelial redox homeostasis in regions of high, unidirectional shear stress (USS), however the underlying mechanosensitive mediators are not fully understood. The endothelial glycocalyx is disrupt...

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Bibliographic Details
Main Authors:	Paraskevi-Maria Psefteli, Phoebe Kitscha, Gema Vizcay, Roland Fleck, Sarah J. Chapple, Giovanni E. Mann, Mark Fowler, Richard C. Siow
Format:	Article
Language:	English
Published:	Elsevier 2021-01-01
Series:	Redox Biology
Subjects:	Endothelial glycocalyx Glutamate-cysteine ligase Heme oxygenase-1 Hemodynamic shear stress Mechanotransduction NAD(P)H quinone oxidoreductase-1
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231720310211

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