CD36/Lyn kinase interactions within macrophages promotes pulmonary fibrosis in response to oxidized phospholipid

CD36/Lyn kinase interactions within macrophages promotes pulmonary fibrosis in response to oxidized phospholipid

Abstract Recent data from human studies and animal models have established roles for type II alveolar epithelial cell (AEC2) injury/apoptosis and monocyte/macrophage accumulation and activation in progressive lung fibrosis. Although the link between these processes is not well defined, we have previ...

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Bibliographic Details
Main Authors: Doyun Kwak, Patrick B. Bradley, Natalia Subbotina, Song Ling, Seagal Teitz-Tennenbaum, John J. Osterholzer, Thomas H. Sisson, Kevin K. Kim
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Respiratory Research
Subjects:
CD36
Oxidized phospholipid
Pulmonary fibrosis
Macrophage
TGFβ
Lyn kinase
Online Access:https://doi.org/10.1186/s12931-023-02629-6

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