Relationship between salivary levels of interleukin‐8 and HbA1c in patients with type 2 diabetes
Abstract Introduction Diabetes mellitus is a metabolic disease, which genetic and environmental factors play a role in its pathogenesis. Cytokines as important elements in the immune system have diverse expressions in different individuals and societies and are effective in the pathogenesis of diabe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Endocrinology, Diabetes & Metabolism |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/edm2.455 |
| _version_ | 1797630823825932288 |
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| author | Masoomeh Shirzaiy Zohreh Dalirsani Payam Peymankar Mahboobeh Taherizadeh |
| author_facet | Masoomeh Shirzaiy Zohreh Dalirsani Payam Peymankar Mahboobeh Taherizadeh |
| author_sort | Masoomeh Shirzaiy |
| collection | DOAJ |
| description | Abstract Introduction Diabetes mellitus is a metabolic disease, which genetic and environmental factors play a role in its pathogenesis. Cytokines as important elements in the immune system have diverse expressions in different individuals and societies and are effective in the pathogenesis of diabetes. This study investigated the relationship between blood sugar control and salivary levels of interleukin‐8 (IL‐8) in patients with type 2 diabetes. Methods This cross‐sectional study was conducted on 73 subjects (35 diabetic and 38 healthy individuals). Unstimulated saliva samples were collected and the correlation between IL‐8, as an inflammatory marker and HbA1c (Haemoglobin A1C) was studied. Results The levels of IL‐8 and HbA1c were significantly higher in the patient group than control group (p < .001, p < .001, respectively). There was not any relationship between salivary IL‐8 levels and glycemic control levels (p = .629). Also, there was no remarkable difference between men and women in terms of the levels of IL‐8 and HbA1c saliva (p = .524, p = .998, respectively). Conclusion Although the salivary IL‐8 levels were higher in the diabetic patients, blood sugar control did not significantly affect cytokine concentrations. Increased salivary levels of IL‐8 in patients with type 2 diabetes could be a basis for risk assessment, prevention and treatment of diabetes‐related complications. |
| first_indexed | 2024-03-11T11:13:16Z |
| format | Article |
| id | doaj.art-39e0f4f3fe4a447d8cdb3a7ecb549eee |
| institution | Directory Open Access Journal |
| issn | 2398-9238 |
| language | English |
| last_indexed | 2024-03-11T11:13:16Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj.art-39e0f4f3fe4a447d8cdb3a7ecb549eee2023-11-11T09:37:05ZengWileyEndocrinology, Diabetes & Metabolism2398-92382023-11-0166n/an/a10.1002/edm2.455Relationship between salivary levels of interleukin‐8 and HbA1c in patients with type 2 diabetesMasoomeh Shirzaiy0Zohreh Dalirsani1Payam Peymankar2Mahboobeh Taherizadeh3Oral and Dental Disease Research Center Zahedan University of Medical Science Zahedan IranOral and Maxillofacial Diseases Research Center Mashhad University of Medical Sciences Mashhad IranOral and Dental Disease Research Center Zahedan University of Medical Science Zahedan IranFaculty of Health Mashhad University of Medical Sciences Mashhad IranAbstract Introduction Diabetes mellitus is a metabolic disease, which genetic and environmental factors play a role in its pathogenesis. Cytokines as important elements in the immune system have diverse expressions in different individuals and societies and are effective in the pathogenesis of diabetes. This study investigated the relationship between blood sugar control and salivary levels of interleukin‐8 (IL‐8) in patients with type 2 diabetes. Methods This cross‐sectional study was conducted on 73 subjects (35 diabetic and 38 healthy individuals). Unstimulated saliva samples were collected and the correlation between IL‐8, as an inflammatory marker and HbA1c (Haemoglobin A1C) was studied. Results The levels of IL‐8 and HbA1c were significantly higher in the patient group than control group (p < .001, p < .001, respectively). There was not any relationship between salivary IL‐8 levels and glycemic control levels (p = .629). Also, there was no remarkable difference between men and women in terms of the levels of IL‐8 and HbA1c saliva (p = .524, p = .998, respectively). Conclusion Although the salivary IL‐8 levels were higher in the diabetic patients, blood sugar control did not significantly affect cytokine concentrations. Increased salivary levels of IL‐8 in patients with type 2 diabetes could be a basis for risk assessment, prevention and treatment of diabetes‐related complications.https://doi.org/10.1002/edm2.455chemokinesdiabetes mellitusHbA1cinterleukin‐8salivatype 2 |
| spellingShingle | Masoomeh Shirzaiy Zohreh Dalirsani Payam Peymankar Mahboobeh Taherizadeh Relationship between salivary levels of interleukin‐8 and HbA1c in patients with type 2 diabetes Endocrinology, Diabetes & Metabolism chemokines diabetes mellitus HbA1c interleukin‐8 saliva type 2 |
| title | Relationship between salivary levels of interleukin‐8 and HbA1c in patients with type 2 diabetes |
| title_full | Relationship between salivary levels of interleukin‐8 and HbA1c in patients with type 2 diabetes |
| title_fullStr | Relationship between salivary levels of interleukin‐8 and HbA1c in patients with type 2 diabetes |
| title_full_unstemmed | Relationship between salivary levels of interleukin‐8 and HbA1c in patients with type 2 diabetes |
| title_short | Relationship between salivary levels of interleukin‐8 and HbA1c in patients with type 2 diabetes |
| title_sort | relationship between salivary levels of interleukin 8 and hba1c in patients with type 2 diabetes |
| topic | chemokines diabetes mellitus HbA1c interleukin‐8 saliva type 2 |
| url | https://doi.org/10.1002/edm2.455 |
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