The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort
In this study, we investigated the risk of thyroid cancer in patients with gout. Participants ≥40 years old in the Korean National Health Insurance Service–Health Screening Cohort were investigated. A total of 5844 patients with thyroid cancer were paired with 23,376 comparison participants (no hist...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/6/887 |
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| author | So Young Kim Dae Myoung Yoo Mi Jung Kwon Ji Hee Kim Joo-Hee Kim Woo Jin Bang Sung Kyun Kim Hyo Geun Choi |
| author_facet | So Young Kim Dae Myoung Yoo Mi Jung Kwon Ji Hee Kim Joo-Hee Kim Woo Jin Bang Sung Kyun Kim Hyo Geun Choi |
| author_sort | So Young Kim |
| collection | DOAJ |
| description | In this study, we investigated the risk of thyroid cancer in patients with gout. Participants ≥40 years old in the Korean National Health Insurance Service–Health Screening Cohort were investigated. A total of 5844 patients with thyroid cancer were paired with 23,376 comparison participants (no history of thyroid cancer) to build the nested case–control study. A previous history of gout was collected from both the thyroid cancer and comparison participants. The relationship of thyroid cancer with a prior history of gout was analyzed using a conditional logistic regression model. The rate of gout was higher in the patients with thyroid cancer than in the comparison group. In the total study population, the relationship of thyroid cancer with a prior history of gout was not statistically evident. A previous history of gout was related to an increased risk of gout in the <60 years old, normal weight, abnormal blood pressure, and CCI score = 0 groups. The occurrence of thyroid cancer was not associated with a prior history of gout in the general adult population. However, a prior history of gout was related to an elevated risk of thyroid cancer in middle-aged and healthy populations without comorbidities. |
| first_indexed | 2024-03-09T23:20:19Z |
| format | Article |
| id | doaj.art-39e117a3bc8a4ec8b077fecbef907ad0 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T23:20:19Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-39e117a3bc8a4ec8b077fecbef907ad02023-11-23T17:27:05ZengMDPI AGJournal of Personalized Medicine2075-44262022-05-0112688710.3390/jpm12060887The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening CohortSo Young Kim0Dae Myoung Yoo1Mi Jung Kwon2Ji Hee Kim3Joo-Hee Kim4Woo Jin Bang5Sung Kyun Kim6Hyo Geun Choi7Bundang CHA Medical Center, Department of Otorhinolaryngology-Head and Neck Surgery, CHA University, Seongnam 13488, KoreaHallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, KoreaDepartment of Pathology, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, KoreaDepartment of Neurosurgery, Hallym University College of Medicine, Anyang 14068, KoreaDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, KoreaDepartment of Urology, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Anyang 14068, KoreaBundang CHA Medical Center, Department of Otorhinolaryngology-Head and Neck Surgery, CHA University, Seongnam 13488, KoreaIn this study, we investigated the risk of thyroid cancer in patients with gout. Participants ≥40 years old in the Korean National Health Insurance Service–Health Screening Cohort were investigated. A total of 5844 patients with thyroid cancer were paired with 23,376 comparison participants (no history of thyroid cancer) to build the nested case–control study. A previous history of gout was collected from both the thyroid cancer and comparison participants. The relationship of thyroid cancer with a prior history of gout was analyzed using a conditional logistic regression model. The rate of gout was higher in the patients with thyroid cancer than in the comparison group. In the total study population, the relationship of thyroid cancer with a prior history of gout was not statistically evident. A previous history of gout was related to an increased risk of gout in the <60 years old, normal weight, abnormal blood pressure, and CCI score = 0 groups. The occurrence of thyroid cancer was not associated with a prior history of gout in the general adult population. However, a prior history of gout was related to an elevated risk of thyroid cancer in middle-aged and healthy populations without comorbidities.https://www.mdpi.com/2075-4426/12/6/887goutthyroid cancerrisk factorscohort studiesepidemiology |
| spellingShingle | So Young Kim Dae Myoung Yoo Mi Jung Kwon Ji Hee Kim Joo-Hee Kim Woo Jin Bang Sung Kyun Kim Hyo Geun Choi The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort Journal of Personalized Medicine gout thyroid cancer risk factors cohort studies epidemiology |
| title | The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort |
| title_full | The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort |
| title_fullStr | The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort |
| title_full_unstemmed | The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort |
| title_short | The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort |
| title_sort | effect of gout on thyroid cancer incidence a nested case control study using a national health screening cohort |
| topic | gout thyroid cancer risk factors cohort studies epidemiology |
| url | https://www.mdpi.com/2075-4426/12/6/887 |
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