Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques

Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques

Abstract A biologically relevant non-human primate (NHP) model of HIV persistence in the central nervous system (CNS) is necessary. Most current NHP/SIV models of HIV infection fail to recapitulate viral persistence in the CNS without encephalitis or fail to employ viruses that authentically represe...

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Bibliographic Details
Main Authors: Rachel M. Podgorski, Jake A. Robinson, Mandy D. Smith, Suvadip Mallick, Huaqing Zhao, Ronald S. Veazey, Dennis L. Kolson, Katharine J. Bar, Tricia H. Burdo
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Retrovirology
Subjects:
SHIV
Non-human primates
HIV
Persistence
NeuroHIV
Online Access:https://doi.org/10.1186/s12977-023-00628-5

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