Guanidinylated Polymyxins as Outer Membrane Permeabilizers Capable of Potentiating Rifampicin, Erythromycin, Ceftazidime and Aztreonam against Gram-Negative Bacteria

Guanidinylated Polymyxins as Outer Membrane Permeabilizers Capable of Potentiating Rifampicin, Erythromycin, Ceftazidime and Aztreonam against Gram-Negative Bacteria

Polymyxins are considered a last-line treatment against infections caused by multidrug-resistant (MDR) Gram-negative bacteria. In addition to their use as a potent antibiotic, polymyxins have also been utilized as outer membrane (OM) permeabilizers, capable of augmenting the activity of a partner an...

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Bibliographic Details
Main Authors: Danzel Marie Ramirez, Danyel Ramirez, Gilbert Arthur, George Zhanel, Frank Schweizer
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Antibiotics
Subjects:
outer membrane permeabilizer
antibiotic potentiator
antibiotic adjuvant
polymyxins
<i>Pseudomonas aeruginosa</i>
<i>Acinetobacter baumannii</i>
Online Access:https://www.mdpi.com/2079-6382/11/10/1277

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