An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers
Apitherapy (using bee products) has gained broad recognition in cancer therapeutics globally. Honeybee venom has a broad range of biological potential, and its utilization is rapidly emerging in apitherapy. Bee products have significant potential to strengthen the immune system and improve human hea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/14/3111 |
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| author | Pratibha Pandey Fahad Khan Minhaj Ahmad Khan Rajnish Kumar Tarun Kumar Upadhyay |
| author_facet | Pratibha Pandey Fahad Khan Minhaj Ahmad Khan Rajnish Kumar Tarun Kumar Upadhyay |
| author_sort | Pratibha Pandey |
| collection | DOAJ |
| description | Apitherapy (using bee products) has gained broad recognition in cancer therapeutics globally. Honeybee venom has a broad range of biological potential, and its utilization is rapidly emerging in apitherapy. Bee products have significant potential to strengthen the immune system and improve human health. Thus, this review is targeted toward recapitulating the chemo-preventive potential of melittin (MEL), which constitutes a substantial portion of honeybee venom. Honeybee venom (apitoxin) is produced in the venom gland of the honeybee abdomen, and adult bees utilize it as a primary colony defense mechanism. Apitoxin comprises numerous biologically active compounds, including peptides, enzymes, amines, amino acids, phospholipids, minerals, carbohydrates, and volatile components. We are mainly focused on exploring the potential of melittin (a peptide component) of bee venom that has shown promising potential in the treatment of several human cancers, including breast, stomach, lung, prostate, ovary, kidney, colon, gastric, esophageal, cervical cancers, melanoma, osteosarcoma, and hepatocellular carcinoma. This review has summarized all potential studies related to the anticancerous efficacy of melittin (apitoxin), its formulations, conjugates, and nano-formulations against several human carcinomas, which would further pave the way for future researchers in developing potent drugs for cancer management. |
| first_indexed | 2024-03-11T00:45:48Z |
| format | Article |
| id | doaj.art-39e26a63c460421a917b0ece05c9423a |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T00:45:48Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-39e26a63c460421a917b0ece05c9423a2023-11-18T20:47:19ZengMDPI AGNutrients2072-66432023-07-011514311110.3390/nu15143111An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human CancersPratibha Pandey0Fahad Khan1Minhaj Ahmad Khan2Rajnish Kumar3Tarun Kumar Upadhyay4Department of Biotechnology, Noida Institute of Engineering & Technology, Greater Noida 201306, Uttar Pradesh, IndiaDepartment of Biotechnology, Noida Institute of Engineering & Technology, Greater Noida 201306, Uttar Pradesh, IndiaDepartment of Biochemistry, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaDepartment of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida 201306, Uttar Pradesh, IndiaDepartment of Biotechnology, Parul Institute of Applied Sciences and Centre of Research for Development, Parul University, Vadodara 391760, Gujarat, IndiaApitherapy (using bee products) has gained broad recognition in cancer therapeutics globally. Honeybee venom has a broad range of biological potential, and its utilization is rapidly emerging in apitherapy. Bee products have significant potential to strengthen the immune system and improve human health. Thus, this review is targeted toward recapitulating the chemo-preventive potential of melittin (MEL), which constitutes a substantial portion of honeybee venom. Honeybee venom (apitoxin) is produced in the venom gland of the honeybee abdomen, and adult bees utilize it as a primary colony defense mechanism. Apitoxin comprises numerous biologically active compounds, including peptides, enzymes, amines, amino acids, phospholipids, minerals, carbohydrates, and volatile components. We are mainly focused on exploring the potential of melittin (a peptide component) of bee venom that has shown promising potential in the treatment of several human cancers, including breast, stomach, lung, prostate, ovary, kidney, colon, gastric, esophageal, cervical cancers, melanoma, osteosarcoma, and hepatocellular carcinoma. This review has summarized all potential studies related to the anticancerous efficacy of melittin (apitoxin), its formulations, conjugates, and nano-formulations against several human carcinomas, which would further pave the way for future researchers in developing potent drugs for cancer management.https://www.mdpi.com/2072-6643/15/14/3111apitherapycancer therapeuticshoneybee venomnanotechnologymelittin |
| spellingShingle | Pratibha Pandey Fahad Khan Minhaj Ahmad Khan Rajnish Kumar Tarun Kumar Upadhyay An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers Nutrients apitherapy cancer therapeutics honeybee venom nanotechnology melittin |
| title | An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers |
| title_full | An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers |
| title_fullStr | An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers |
| title_full_unstemmed | An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers |
| title_short | An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers |
| title_sort | updated review summarizing the anticancer efficacy of melittin from bee venom in several models of human cancers |
| topic | apitherapy cancer therapeutics honeybee venom nanotechnology melittin |
| url | https://www.mdpi.com/2072-6643/15/14/3111 |
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