Shrinking Fabrication of a Glucose‐Responsive Glucagon Microneedle Patch
Abstract A microdevice that offers glucagon supplements in a safe, non‐invasive, and glucose‐responsive manner is ideal for avoiding fatal hypoglycemia consequences from insulin overdosage during daily diabetes treatment. However, mold‐assisted microfabrication of biomedical materials or devices typ...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202203274 |
| _version_ | 1828162441351004160 |
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| author | Zejun Wang Ruxing Fu Xiao Han Di Wen Yifan Wu Song Li Zhen Gu |
| author_facet | Zejun Wang Ruxing Fu Xiao Han Di Wen Yifan Wu Song Li Zhen Gu |
| author_sort | Zejun Wang |
| collection | DOAJ |
| description | Abstract A microdevice that offers glucagon supplements in a safe, non‐invasive, and glucose‐responsive manner is ideal for avoiding fatal hypoglycemia consequences from insulin overdosage during daily diabetes treatment. However, mold‐assisted microfabrication of biomedical materials or devices typically needs high‐resolution laser ablation to scale down structural design. In addition, the majority of the polymeric drug delivery materials being used to fabricate devices are dissolvable or deformable in aqueous environments, which restricts washing‐based cleaning and purification procedures post shape fixation. This study leverages the design flexibility of 3D printing‐assisted mold casting and presents a shrinking microfabrication approach that allows subsequent washing procedures to remove toxic monomer residues during polymerization. The feasibility of this approach is demonstrated by developing a glucose‐responsive transdermal glucagon microneedle patch through matrix volume change‐mediated release kinetic control. Shown in the type 1 diabetic mouse model, this transdermal patch can reverse the occurrence of hypoglycemia while lowering the risk of monomer residue‐induced irritation during treatment. Freeing from the restrain of molding resolution for microstructure design, this shrinking methodology further provides an insight into post‐fabrication purifications of biomedical materials. |
| first_indexed | 2024-04-12T00:54:20Z |
| format | Article |
| id | doaj.art-39e2db8e837146c790f9c1206ae4a203 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-12T00:54:20Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-39e2db8e837146c790f9c1206ae4a2032022-12-22T03:54:38ZengWileyAdvanced Science2198-38442022-10-01928n/an/a10.1002/advs.202203274Shrinking Fabrication of a Glucose‐Responsive Glucagon Microneedle PatchZejun Wang0Ruxing Fu1Xiao Han2Di Wen3Yifan Wu4Song Li5Zhen Gu6Department of Bioengineering University of California Los Angeles CA 90095 USADepartment of Bioengineering University of California Los Angeles CA 90095 USADepartment of Bioengineering University of California Los Angeles CA 90095 USADepartment of Bioengineering University of California Los Angeles CA 90095 USADepartment of Bioengineering University of California Los Angeles CA 90095 USADepartment of Bioengineering University of California Los Angeles CA 90095 USADepartment of Bioengineering University of California Los Angeles CA 90095 USAAbstract A microdevice that offers glucagon supplements in a safe, non‐invasive, and glucose‐responsive manner is ideal for avoiding fatal hypoglycemia consequences from insulin overdosage during daily diabetes treatment. However, mold‐assisted microfabrication of biomedical materials or devices typically needs high‐resolution laser ablation to scale down structural design. In addition, the majority of the polymeric drug delivery materials being used to fabricate devices are dissolvable or deformable in aqueous environments, which restricts washing‐based cleaning and purification procedures post shape fixation. This study leverages the design flexibility of 3D printing‐assisted mold casting and presents a shrinking microfabrication approach that allows subsequent washing procedures to remove toxic monomer residues during polymerization. The feasibility of this approach is demonstrated by developing a glucose‐responsive transdermal glucagon microneedle patch through matrix volume change‐mediated release kinetic control. Shown in the type 1 diabetic mouse model, this transdermal patch can reverse the occurrence of hypoglycemia while lowering the risk of monomer residue‐induced irritation during treatment. Freeing from the restrain of molding resolution for microstructure design, this shrinking methodology further provides an insight into post‐fabrication purifications of biomedical materials.https://doi.org/10.1002/advs.2022032743D printingdrug deliveryglucose‐responsiveshrinkingwashable |
| spellingShingle | Zejun Wang Ruxing Fu Xiao Han Di Wen Yifan Wu Song Li Zhen Gu Shrinking Fabrication of a Glucose‐Responsive Glucagon Microneedle Patch Advanced Science 3D printing drug delivery glucose‐responsive shrinking washable |
| title | Shrinking Fabrication of a Glucose‐Responsive Glucagon Microneedle Patch |
| title_full | Shrinking Fabrication of a Glucose‐Responsive Glucagon Microneedle Patch |
| title_fullStr | Shrinking Fabrication of a Glucose‐Responsive Glucagon Microneedle Patch |
| title_full_unstemmed | Shrinking Fabrication of a Glucose‐Responsive Glucagon Microneedle Patch |
| title_short | Shrinking Fabrication of a Glucose‐Responsive Glucagon Microneedle Patch |
| title_sort | shrinking fabrication of a glucose responsive glucagon microneedle patch |
| topic | 3D printing drug delivery glucose‐responsive shrinking washable |
| url | https://doi.org/10.1002/advs.202203274 |
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