A facile approach for the in vitro assembly of multimeric membrane transport proteins

A facile approach for the in vitro assembly of multimeric membrane transport proteins

Membrane proteins such as ion channels and transporters are frequently homomeric. The homomeric nature raises important questions regarding coupling between subunits and complicates the application of techniques such as FRET or DEER spectroscopy. These challenges can be overcome if the subunits of a...

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Bibliographic Details
Main Authors: Erika A Riederer, Paul J Focke, Elka R Georgieva, Nurunisa Akyuz, Kimberly Matulef, Peter P Borbat, Jack H Freed, Scott C Blanchard, Olga Boudker, Francis I Valiyaveetil
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
membrane proteins
in vitro folding
DEER
FRET
multimerization
transporters
Online Access:https://elifesciences.org/articles/36478

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