Metastatic clear cell carcinoma of the kidney: therapeutic role of bevacizumab
Ronald M BukowskiCleveland Clinic Taussig Cancer Center, CCF Lerner College of Medicine of CWRU Cleveland, OH, USAAbstract: The biology and pathogenesis of clear cell carcinoma of the kidney has been extensively investgated, and the role of von Hipple-Landau gene inactivation and tumor associated an...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2010-03-01
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| Series: | Cancer Management and Research |
| Online Access: | http://www.dovepress.com/metastatic-clear-cell-carcinoma-of-the-kidney-therapeutic-role-of-beva-a4132 |
| _version_ | 1811283932570714112 |
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| author | Ronald M Bukowski |
| author_facet | Ronald M Bukowski |
| author_sort | Ronald M Bukowski |
| collection | DOAJ |
| description | Ronald M BukowskiCleveland Clinic Taussig Cancer Center, CCF Lerner College of Medicine of CWRU Cleveland, OH, USAAbstract: The biology and pathogenesis of clear cell carcinoma of the kidney has been extensively investgated, and the role of von Hipple-Landau gene inactivation and tumor associated angiogenesis is now recognized. Development of vascular endothelial growth factor inhibitors and phase 3 clinical trials utilizing this class of agents has produced a new treatment paradigm for patients with metastatic renal cell carcinoma (RCC). One of the active regimens identified is the combination of bevacizumab and interferon-α. Recently published reports provided evidence of the clinical and biologic activity of this therapy. The current manuscript reviews the background and rationale for the activity of bevacizumab in RCC, and results from recent clinical trials with this agent alone or in combination with targeted agents or cytokines. The role of this therapy in contrast to other targeted agents is reviewed, and the potential utility as well as questions raised by recent studies are discussed.Keywords: metastatic renal cell carcinoma, bevacizumab, interferon-α |
| first_indexed | 2024-04-13T02:20:59Z |
| format | Article |
| id | doaj.art-39e6eeacfe864cc387bc736619ae1527 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-04-13T02:20:59Z |
| publishDate | 2010-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-39e6eeacfe864cc387bc736619ae15272022-12-22T03:06:59ZengDove Medical PressCancer Management and Research1179-13222010-03-012010default8396Metastatic clear cell carcinoma of the kidney: therapeutic role of bevacizumabRonald M BukowskiRonald M BukowskiCleveland Clinic Taussig Cancer Center, CCF Lerner College of Medicine of CWRU Cleveland, OH, USAAbstract: The biology and pathogenesis of clear cell carcinoma of the kidney has been extensively investgated, and the role of von Hipple-Landau gene inactivation and tumor associated angiogenesis is now recognized. Development of vascular endothelial growth factor inhibitors and phase 3 clinical trials utilizing this class of agents has produced a new treatment paradigm for patients with metastatic renal cell carcinoma (RCC). One of the active regimens identified is the combination of bevacizumab and interferon-α. Recently published reports provided evidence of the clinical and biologic activity of this therapy. The current manuscript reviews the background and rationale for the activity of bevacizumab in RCC, and results from recent clinical trials with this agent alone or in combination with targeted agents or cytokines. The role of this therapy in contrast to other targeted agents is reviewed, and the potential utility as well as questions raised by recent studies are discussed.Keywords: metastatic renal cell carcinoma, bevacizumab, interferon-αhttp://www.dovepress.com/metastatic-clear-cell-carcinoma-of-the-kidney-therapeutic-role-of-beva-a4132 |
| spellingShingle | Ronald M Bukowski Metastatic clear cell carcinoma of the kidney: therapeutic role of bevacizumab Cancer Management and Research |
| title | Metastatic clear cell carcinoma of the kidney: therapeutic role of bevacizumab |
| title_full | Metastatic clear cell carcinoma of the kidney: therapeutic role of bevacizumab |
| title_fullStr | Metastatic clear cell carcinoma of the kidney: therapeutic role of bevacizumab |
| title_full_unstemmed | Metastatic clear cell carcinoma of the kidney: therapeutic role of bevacizumab |
| title_short | Metastatic clear cell carcinoma of the kidney: therapeutic role of bevacizumab |
| title_sort | metastatic clear cell carcinoma of the kidney therapeutic role of bevacizumab |
| url | http://www.dovepress.com/metastatic-clear-cell-carcinoma-of-the-kidney-therapeutic-role-of-beva-a4132 |
| work_keys_str_mv | AT ronaldmbukowski metastaticclearcellcarcinomaofthekidneytherapeuticroleofbevacizumab |