AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1
Signaling via the mTOR complex 1 (mTORC1) maintains cellular and organismal homeostasis. Here the authors show that the AAA + ATPase Thorase binds mTOR to promote disassembly and inactivation of mTORC1 to fine tune TOR signaling according to amino acid availability.
Bibliographic Details
| Main Authors: |
George K. E. Umanah,
Leire Abalde-Atristain,
Mohammed Repon Khan,
Jaba Mitra,
Mohamad Aasif Dar,
Melissa Chang,
Kavya Tangella,
Amy McNamara,
Samuel Bennett,
Rong Chen,
Vasudha Aggarwal,
Marisol Cortes,
Paul F. Worley,
Taekjip Ha,
Ted M. Dawson,
Valina L. Dawson |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-32365-2
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