AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1
Signaling via the mTOR complex 1 (mTORC1) maintains cellular and organismal homeostasis. Here the authors show that the AAA + ATPase Thorase binds mTOR to promote disassembly and inactivation of mTORC1 to fine tune TOR signaling according to amino acid availability.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32365-2 |
| _version_ | 1811340344354144256 |
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| author | George K. E. Umanah Leire Abalde-Atristain Mohammed Repon Khan Jaba Mitra Mohamad Aasif Dar Melissa Chang Kavya Tangella Amy McNamara Samuel Bennett Rong Chen Vasudha Aggarwal Marisol Cortes Paul F. Worley Taekjip Ha Ted M. Dawson Valina L. Dawson |
| author_facet | George K. E. Umanah Leire Abalde-Atristain Mohammed Repon Khan Jaba Mitra Mohamad Aasif Dar Melissa Chang Kavya Tangella Amy McNamara Samuel Bennett Rong Chen Vasudha Aggarwal Marisol Cortes Paul F. Worley Taekjip Ha Ted M. Dawson Valina L. Dawson |
| author_sort | George K. E. Umanah |
| collection | DOAJ |
| description | Signaling via the mTOR complex 1 (mTORC1) maintains cellular and organismal homeostasis. Here the authors show that the AAA + ATPase Thorase binds mTOR to promote disassembly and inactivation of mTORC1 to fine tune TOR signaling according to amino acid availability. |
| first_indexed | 2024-04-13T18:40:37Z |
| format | Article |
| id | doaj.art-39e9bfd4fe0d4b70af60f3ca585b52ec |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T18:40:37Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-39e9bfd4fe0d4b70af60f3ca585b52ec2022-12-22T02:34:44ZengNature PortfolioNature Communications2041-17232022-08-0113111810.1038/s41467-022-32365-2AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1George K. E. Umanah0Leire Abalde-Atristain1Mohammed Repon Khan2Jaba Mitra3Mohamad Aasif Dar4Melissa Chang5Kavya Tangella6Amy McNamara7Samuel Bennett8Rong Chen9Vasudha Aggarwal10Marisol Cortes11Paul F. Worley12Taekjip Ha13Ted M. Dawson14Valina L. Dawson15Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineDepartment of Materials Science and Engineering, University of Illinois at Urbana-ChampaignNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins UniversityNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of MedicineDepartments of Biophysics and Biophysical Chemistry, Biophysics and Biomedical Engineering, JHU Howard Hughes Medical InstituteNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of MedicineSignaling via the mTOR complex 1 (mTORC1) maintains cellular and organismal homeostasis. Here the authors show that the AAA + ATPase Thorase binds mTOR to promote disassembly and inactivation of mTORC1 to fine tune TOR signaling according to amino acid availability.https://doi.org/10.1038/s41467-022-32365-2 |
| spellingShingle | George K. E. Umanah Leire Abalde-Atristain Mohammed Repon Khan Jaba Mitra Mohamad Aasif Dar Melissa Chang Kavya Tangella Amy McNamara Samuel Bennett Rong Chen Vasudha Aggarwal Marisol Cortes Paul F. Worley Taekjip Ha Ted M. Dawson Valina L. Dawson AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1 Nature Communications |
| title | AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1 |
| title_full | AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1 |
| title_fullStr | AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1 |
| title_full_unstemmed | AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1 |
| title_short | AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1 |
| title_sort | aaa atpase thorase inhibits mtor signaling through the disassembly of the mtor complex 1 |
| url | https://doi.org/10.1038/s41467-022-32365-2 |
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