The impact of pulmonary tuberculosis on immunological and metabolic features of diabetic patients
Impaired immune responses have been observed in patients with type-2 diabetes mellitus (T2DM), which increases susceptibility to tuberculosis infection. However, the effect of the tuberculosis infection on the immunological and metabolic features of T2DM is largely unknown. To investigate this quest...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.973991/full |
| _version_ | 1818497205004140544 |
|---|---|
| author | Haijun Chen Li Su Jinhua Bao Kun Zhang Yuze Li Yuze Li Enuo Mao |
| author_facet | Haijun Chen Li Su Jinhua Bao Kun Zhang Yuze Li Yuze Li Enuo Mao |
| author_sort | Haijun Chen |
| collection | DOAJ |
| description | Impaired immune responses have been observed in patients with type-2 diabetes mellitus (T2DM), which increases susceptibility to tuberculosis infection. However, the effect of the tuberculosis infection on the immunological and metabolic features of T2DM is largely unknown. To investigate this question, age- and sex-matched patients with pulmonary tuberculosis (PTB), T2DM, or T2DM combined with PTB were recruited from the Infectious Disease Hospital of Heilongjiang Province between January and September 2020. Healthy subjects were used as controls. Cytokines and chemokines in fasting serum samples were determined using the Quantibody Inflammation Array. Compared with T2DM alone, patients with T2DM combined with PTB have higher fasting blood glucose levels and monocyte counts in circulation. Among the four groups, circulating IL-10 levels peaked in patients with T2DM and PTB (p<0.05). Univariate linear analysis showed that serum IL-10 levels were positively associated with myeloid cells but negatively correlated with lymphocyte counts in these patients (p<0.05). Serum IL-6 levels were 1.6-fold higher in patients with T2DM plus PTB than in those with T2DM alone. In conclusion, PTB infection in patients with T2DM had distinct inflammatory profiles and sustained hyperglycaemia compared with PTB or T2DM alone. IL-10 levels and elevated monocyte counts could be hallmarks of patients with T2DM infected with PTB. |
| first_indexed | 2024-12-10T18:42:47Z |
| format | Article |
| id | doaj.art-39eaa85388124a72abe59377d9112e6b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T18:42:47Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-39eaa85388124a72abe59377d9112e6b2022-12-22T01:37:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.973991973991The impact of pulmonary tuberculosis on immunological and metabolic features of diabetic patientsHaijun Chen0Li Su1Jinhua Bao2Kun Zhang3Yuze Li4Yuze Li5Enuo Mao6Department of Computed Tomography, Heilongjiang Provincial Hospital, Harbin, ChinaNeuroscience Research Institute, Peking University Center of Medical and Health Analysis, Peking University, Beijing, ChinaCollege of Sports and Human Sciences, Harbin Sport University, Harbin, ChinaDepartment of Clinical Nutrition, Heilongjiang Provincial Hospital, Harbin, ChinaDepartment of Clinical Nutrition, Heilongjiang Provincial Hospital, Harbin, ChinaDepartment of the Fourth Internal Medicine, The Fourth Hospital of Heilongjiang Province, Harbin, ChinaDepartment of Discipline Inspection and Supervision, Heilongjiang Provincial Hospital, Harbin, ChinaImpaired immune responses have been observed in patients with type-2 diabetes mellitus (T2DM), which increases susceptibility to tuberculosis infection. However, the effect of the tuberculosis infection on the immunological and metabolic features of T2DM is largely unknown. To investigate this question, age- and sex-matched patients with pulmonary tuberculosis (PTB), T2DM, or T2DM combined with PTB were recruited from the Infectious Disease Hospital of Heilongjiang Province between January and September 2020. Healthy subjects were used as controls. Cytokines and chemokines in fasting serum samples were determined using the Quantibody Inflammation Array. Compared with T2DM alone, patients with T2DM combined with PTB have higher fasting blood glucose levels and monocyte counts in circulation. Among the four groups, circulating IL-10 levels peaked in patients with T2DM and PTB (p<0.05). Univariate linear analysis showed that serum IL-10 levels were positively associated with myeloid cells but negatively correlated with lymphocyte counts in these patients (p<0.05). Serum IL-6 levels were 1.6-fold higher in patients with T2DM plus PTB than in those with T2DM alone. In conclusion, PTB infection in patients with T2DM had distinct inflammatory profiles and sustained hyperglycaemia compared with PTB or T2DM alone. IL-10 levels and elevated monocyte counts could be hallmarks of patients with T2DM infected with PTB.https://www.frontiersin.org/articles/10.3389/fimmu.2022.973991/fulltype-2 diabetes mellituspulmonary tuberculosiscytokinesmonocytesinterleukin 10 |
| spellingShingle | Haijun Chen Li Su Jinhua Bao Kun Zhang Yuze Li Yuze Li Enuo Mao The impact of pulmonary tuberculosis on immunological and metabolic features of diabetic patients Frontiers in Immunology type-2 diabetes mellitus pulmonary tuberculosis cytokines monocytes interleukin 10 |
| title | The impact of pulmonary tuberculosis on immunological and metabolic features of diabetic patients |
| title_full | The impact of pulmonary tuberculosis on immunological and metabolic features of diabetic patients |
| title_fullStr | The impact of pulmonary tuberculosis on immunological and metabolic features of diabetic patients |
| title_full_unstemmed | The impact of pulmonary tuberculosis on immunological and metabolic features of diabetic patients |
| title_short | The impact of pulmonary tuberculosis on immunological and metabolic features of diabetic patients |
| title_sort | impact of pulmonary tuberculosis on immunological and metabolic features of diabetic patients |
| topic | type-2 diabetes mellitus pulmonary tuberculosis cytokines monocytes interleukin 10 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.973991/full |
| work_keys_str_mv | AT haijunchen theimpactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT lisu theimpactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT jinhuabao theimpactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT kunzhang theimpactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT yuzeli theimpactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT yuzeli theimpactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT enuomao theimpactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT haijunchen impactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT lisu impactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT jinhuabao impactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT kunzhang impactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT yuzeli impactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT yuzeli impactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients AT enuomao impactofpulmonarytuberculosisonimmunologicalandmetabolicfeaturesofdiabeticpatients |