CRISPR-Cas9-Based Discovery of the Verrucosidin Biosynthesis Gene Cluster in Penicillium polonicum

CRISPR-Cas9-Based Discovery of the Verrucosidin Biosynthesis Gene Cluster in Penicillium polonicum

Penicillium polonicum, commonly found on food matrices, is a mycotoxigenic species able to produce a neurotoxin called verrucosidin. This methylated α-pyrone polyketide inhibits oxidative phosphorylation in mitochondria and thereby causes neurological diseases. Despite the importance of verrucosidin...

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Bibliographic Details
Main Authors: Silvia Valente, Edoardo Piombo, Volker Schroeckh, Giovanna Roberta Meloni, Thorsten Heinekamp, Axel A. Brakhage, Davide Spadaro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Microbiology
Subjects:
secondary metabolites
Penicillium
mycotoxins
CRISPR-Cas
alpha-pyrone polyketides
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.660871/full

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