Increased Urinary Neopterin Excretion in Vaccinated Adults
Serial urinary neopterin :creatinine ratios of 58 healthy adult sub jects were measured from 2 days prior to and up to 12 days post vaccination. An increase in the urinary neopterin of at least twice the baseline was detected in 24/ 46 subjects who received either a Mantoux skin test or a live viral...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
1996-08-01
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| Series: | Pteridines |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pteridines.1996.7.3.82 |
| _version_ | 1818669026699640832 |
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| author | Giovannoni Gavin Bell Joan Feldmann Marc Thompson Edward J. |
| author_facet | Giovannoni Gavin Bell Joan Feldmann Marc Thompson Edward J. |
| author_sort | Giovannoni Gavin |
| collection | DOAJ |
| description | Serial urinary neopterin :creatinine ratios of 58 healthy adult sub jects were measured from 2 days prior to and up to 12 days post vaccination. An increase in the urinary neopterin of at least twice the baseline was detected in 24/ 46 subjects who received either a Mantoux skin test or a live viral vaccine (cell mediated immune group, median average increase above baseline = 206%(interquartile range 150-338% ), and 'in 5/12 who received non-live vaccines known to stimulate mainly humoral immunity (humoral immune group, median average increase above baseline = 165%((interquartile range 142-412%) ). The peaks in the urinary neopterin in the cell mediated group occurred between days 5 and 10 post-vaccination, with the mode on day 5. In contrast the 5 subjects in the humoral immune group all developed their peaks on day 7 or 8 . Three of these subjects received an influenza vaccine, one a typhoid vaccine and one a tetanus toxoid. No association was found between local or systemic side-effects of vaccination and raised urinary neopterin . In conclusion, the monitoring of urinary neopterin excretion in adults is sensitive enough to detect an immunological response to vaccination with immunogens that induce either cell mediated or humoral immune responses. |
| first_indexed | 2024-12-17T06:45:40Z |
| format | Article |
| id | doaj.art-39ed65bcd5ad4de880a40d0123ca5efb |
| institution | Directory Open Access Journal |
| issn | 0933-4807 2195-4720 |
| language | English |
| last_indexed | 2024-12-17T06:45:40Z |
| publishDate | 1996-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pteridines |
| spelling | doaj.art-39ed65bcd5ad4de880a40d0123ca5efb2022-12-21T21:59:44ZengDe GruyterPteridines0933-48072195-47201996-08-0173828610.1515/pteridines.1996.7.3.82Increased Urinary Neopterin Excretion in Vaccinated AdultsGiovannoni Gavin0Bell Joan1Feldmann Marc2Thompson Edward J.3Departments of Neuroimmunology and 20ccupational Health, Institute of Neurology, Queen Square , London WCIN 3BG, and the 3Kennedy Institute of Rheumatology, Hammersmith, London W6 8LWDepartments of Neuroimmunology and 20ccupational Health, Institute of Neurology, Queen Square , London WCIN 3BG, and the 3Kennedy Institute of Rheumatology, Hammersmith, London W6 8LWDepartments of Neuroimmunology and 20ccupational Health, Institute of Neurology, Queen Square , London WCIN 3BG, and the 3Kennedy Institute of Rheumatology, Hammersmith, London W6 8LWDepartments of Neuroimmunology and 20ccupational Health, Institute of Neurology, Queen Square , London WCIN 3BG, and the 3Kennedy Institute of Rheumatology, Hammersmith, London W6 8LWSerial urinary neopterin :creatinine ratios of 58 healthy adult sub jects were measured from 2 days prior to and up to 12 days post vaccination. An increase in the urinary neopterin of at least twice the baseline was detected in 24/ 46 subjects who received either a Mantoux skin test or a live viral vaccine (cell mediated immune group, median average increase above baseline = 206%(interquartile range 150-338% ), and 'in 5/12 who received non-live vaccines known to stimulate mainly humoral immunity (humoral immune group, median average increase above baseline = 165%((interquartile range 142-412%) ). The peaks in the urinary neopterin in the cell mediated group occurred between days 5 and 10 post-vaccination, with the mode on day 5. In contrast the 5 subjects in the humoral immune group all developed their peaks on day 7 or 8 . Three of these subjects received an influenza vaccine, one a typhoid vaccine and one a tetanus toxoid. No association was found between local or systemic side-effects of vaccination and raised urinary neopterin . In conclusion, the monitoring of urinary neopterin excretion in adults is sensitive enough to detect an immunological response to vaccination with immunogens that induce either cell mediated or humoral immune responses.https://doi.org/10.1515/pteridines.1996.7.3.82neopterinvaccinationpurified protein derivativeskin tests |
| spellingShingle | Giovannoni Gavin Bell Joan Feldmann Marc Thompson Edward J. Increased Urinary Neopterin Excretion in Vaccinated Adults Pteridines neopterin vaccination purified protein derivative skin tests |
| title | Increased Urinary Neopterin Excretion in Vaccinated Adults |
| title_full | Increased Urinary Neopterin Excretion in Vaccinated Adults |
| title_fullStr | Increased Urinary Neopterin Excretion in Vaccinated Adults |
| title_full_unstemmed | Increased Urinary Neopterin Excretion in Vaccinated Adults |
| title_short | Increased Urinary Neopterin Excretion in Vaccinated Adults |
| title_sort | increased urinary neopterin excretion in vaccinated adults |
| topic | neopterin vaccination purified protein derivative skin tests |
| url | https://doi.org/10.1515/pteridines.1996.7.3.82 |
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