Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment
Introduction Neuropsychiatric symptoms (NPS) are common during the course of neurocognitive disorders. NPS have been previously reported in early and late stages of Alzheimer’s Disease. However, our understanding of NPS in high-risk states for dementia such as mild cognitive impairment (MCI) and ma...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823004169/type/journal_article |
| _version_ | 1797616424084045824 |
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| author | A. Keng D. Kapustin C. Ma K. Bingham C. Fischer L. Mah D. Gallagher M. A. Butters C. R. Bowie A. Voineskos A. Graff A. Flint N. Herrmann B. Pollock B. Mulsant T. Rajji S. Kumar P.-M. Study Group |
| author_facet | A. Keng D. Kapustin C. Ma K. Bingham C. Fischer L. Mah D. Gallagher M. A. Butters C. R. Bowie A. Voineskos A. Graff A. Flint N. Herrmann B. Pollock B. Mulsant T. Rajji S. Kumar P.-M. Study Group |
| author_sort | A. Keng |
| collection | DOAJ |
| description |
Introduction
Neuropsychiatric symptoms (NPS) are common during the course of neurocognitive disorders. NPS have been previously reported in early and late stages of Alzheimer’s Disease. However, our understanding of NPS in high-risk states for dementia such as mild cognitive impairment (MCI) and major depressive disorder (MDD) is poor.
Objectives
To compare the frequency and factor structure of neuropsychiatric symptoms among individuals with Mild Cognitive Impairment (MCI), Major Depressive Disorder (MDD) in remission, and comorbid MCI and MDD (in remission) (MCI-D).
Methods
We used baseline data from the Prevention of Alzheimer’s Dementia with Cognitive Remediation Plus Transcranial Direct Current Stimulation in Mild Cognitive Impairment and Depression (PACt-MD) study, a multicenter trial across five academic sites in Toronto, Canada (clinical trial No. NCT0238667). We used ANOVA or χ2-test to compare frequency of NPS across groups. We used factor analysis of Neuropsychiatric Inventory Questionnaire (NPI-Q) items in the three groups.
Results
We included 374 participants with a mean age of 72.0 years (SD = 6.3). In the overall sample, at least one NPS was present in 64.2% participants, and 36.1 % had at least moderate severity NPS (36.1%). Depression (54%, χ2 < 0.001) and apathy (28.7%, χ2=0.002) were more prevalent in the MCI-D group as compared to MCI and MDD groups. In factor analysis, NPS grouped differently in MCI, MDD, and MCI-D groups. A “psychotic” subgroup emerged among MCI and MCI-D, but not in MDD. Night-time behaviors and disinhibition grouped differently across all three groups.
Conclusions
Prevalence of NPS seems higher in persons with MCI-D as compared to those with only MCI or MDD. The factor structure of NPS differed between MCI, MDD, and MCI-D groups. Future studies should investigate the association of NPS factors with cognition, function, and illness biomarkers.
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:40:57Z |
| format | Article |
| id | doaj.art-39f311d3a3704d4faaaa97ecbe13c55e |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:40:57Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-39f311d3a3704d4faaaa97ecbe13c55e2023-11-17T05:08:30ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S173S17310.1192/j.eurpsy.2023.416Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairmentA. Keng0D. Kapustin1C. Ma2K. Bingham3C. Fischer4L. Mah5D. Gallagher6M. A. Butters7C. R. Bowie8A. Voineskos9A. Graff10A. Flint11N. Herrmann12B. Pollock13B. Mulsant14T. Rajji15S. Kumar16P.-M. Study Group171Psychiatry, University of Toronto 2Psychiatry, Baycrest Hospital1Psychiatry, University of Toronto3Centre for Addictions and Mental Health 4Dalla Lana School of Public Health, University of Toronto1Psychiatry, University of Toronto 5Psychiatry, University Health Network1Psychiatry, University of Toronto 6Psychiatry, Unity Health, Toronto1Psychiatry, University of Toronto 7Psychiatry, Baycrest Hospital1Psychiatry, University of Toronto 8Psychiatry, Sunnybrook Hospital, North York9Psychiatry, University of Pittsburgh, Pittsburgh10Psychiatry, Queens University, Kingston1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada1Psychiatry, University of Toronto 5Psychiatry, University Health Network1Psychiatry, University of Toronto 8Psychiatry, Sunnybrook Hospital, North York1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada1Psychiatry, University of Toronto 11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada11Psychiatry, Centre for Addictions and Mental Health, Toronto, Canada Introduction Neuropsychiatric symptoms (NPS) are common during the course of neurocognitive disorders. NPS have been previously reported in early and late stages of Alzheimer’s Disease. However, our understanding of NPS in high-risk states for dementia such as mild cognitive impairment (MCI) and major depressive disorder (MDD) is poor. Objectives To compare the frequency and factor structure of neuropsychiatric symptoms among individuals with Mild Cognitive Impairment (MCI), Major Depressive Disorder (MDD) in remission, and comorbid MCI and MDD (in remission) (MCI-D). Methods We used baseline data from the Prevention of Alzheimer’s Dementia with Cognitive Remediation Plus Transcranial Direct Current Stimulation in Mild Cognitive Impairment and Depression (PACt-MD) study, a multicenter trial across five academic sites in Toronto, Canada (clinical trial No. NCT0238667). We used ANOVA or χ2-test to compare frequency of NPS across groups. We used factor analysis of Neuropsychiatric Inventory Questionnaire (NPI-Q) items in the three groups. Results We included 374 participants with a mean age of 72.0 years (SD = 6.3). In the overall sample, at least one NPS was present in 64.2% participants, and 36.1 % had at least moderate severity NPS (36.1%). Depression (54%, χ2 < 0.001) and apathy (28.7%, χ2=0.002) were more prevalent in the MCI-D group as compared to MCI and MDD groups. In factor analysis, NPS grouped differently in MCI, MDD, and MCI-D groups. A “psychotic” subgroup emerged among MCI and MCI-D, but not in MDD. Night-time behaviors and disinhibition grouped differently across all three groups. Conclusions Prevalence of NPS seems higher in persons with MCI-D as compared to those with only MCI or MDD. The factor structure of NPS differed between MCI, MDD, and MCI-D groups. Future studies should investigate the association of NPS factors with cognition, function, and illness biomarkers. Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823004169/type/journal_article |
| spellingShingle | A. Keng D. Kapustin C. Ma K. Bingham C. Fischer L. Mah D. Gallagher M. A. Butters C. R. Bowie A. Voineskos A. Graff A. Flint N. Herrmann B. Pollock B. Mulsant T. Rajji S. Kumar P.-M. Study Group Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment European Psychiatry |
| title | Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment |
| title_full | Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment |
| title_fullStr | Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment |
| title_full_unstemmed | Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment |
| title_short | Comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment |
| title_sort | comparing the distribution of neuropsychiatric symptoms among individuals with depression and mild cognitive impairment |
| url | https://www.cambridge.org/core/product/identifier/S0924933823004169/type/journal_article |
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